BBIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0015031Biological processprotein transport
GO_0097500Biological processreceptor localization to non-motile cilium
GO_0042755Biological processeating behavior
GO_0060170Cellular componentciliary membrane
GO_0005829Cellular componentcytosol
GO_0034464Cellular componentBBSome
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBBIP1
Protein nameBBSome interacting protein 1
BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa)
SynonymsBBIP10
NCRNA00081
DescriptionFUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation. .

AccessionsENST00000398289.2
A0A494C180
ENST00000454061.5 [A8MTZ0-4]
ENST00000448814.7 [A8MTZ0-1]
ENST00000605742.5 [A8MTZ0-1]
ENST00000652396.1 [A8MTZ0-2]
ENST00000652043.1 [A8MTZ0-1]
ENST00000651766.1
E9PIK7
ENST00000651952.1 [A8MTZ0-2]
ENST00000436562.1 [A8MTZ0-2]
ENST00000423273.5 [A8MTZ0-3]
ENST00000652400.1 [A8MTZ0-2]
A8MTZ0
ENST00000447005.5 [A8MTZ0-2]