BAG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0090083Biological processregulation of inclusion body assembly
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0061084Biological processnegative regulation of protein refolding
GO_0006457Biological processprotein folding
GO_0007030Biological processGolgi organization
GO_0051438Biological processregulation of ubiquitin-protein transferase activity
GO_0010977Biological processnegative regulation of neuron projection development
GO_0050821Biological processprotein stabilization
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0016234Cellular componentinclusion body
GO_0005829Cellular componentcytosol
GO_0030314Cellular componentjunctional membrane complex
GO_0005737Cellular componentcytoplasm
GO_0000774Molecular functionadenyl-nucleotide exchange factor activity
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBAG5
Protein nameBCL2-associated athanogene 5
BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
BAG family molecular chaperone regulator 5 (Bcl-2-associated athanogene 5)
SynonymsKIAA0873
hCG_25497
DescriptionFUNCTION: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding . Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). .

AccessionsENST00000299204.6 [Q9UL15-1]
A8CGI4
Q9UL15
A0A024R6M6
ENST00000337322.5 [Q9UL15-1]
ENST00000445922.2 [Q9UL15-1]