B4GAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007411Biological processaxon guidance
GO_0030311Biological processpoly-N-acetyllactosamine biosynthetic process
GO_0035269Biological processprotein O-linked mannosylation
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008532Molecular functionN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameB4GAT1
Protein nameBeta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)
SynonymsB3GNT1
B3GNT6
DescriptionFUNCTION: Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) . Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan . Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity . Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity). .

AccessionsO43505
ENST00000311181.5