B4GALT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006643Biological processmembrane lipid metabolic process
GO_0005975Biological processcarbohydrate metabolic process
GO_0006486Biological processprotein glycosylation
GO_0070085Biological processglycosylation
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0001572Biological processlactosylceramide biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0008378Molecular functiongalactosyltransferase activity
GO_0003945Molecular functionN-acetyllactosamine synthase activity
GO_0005515Molecular functionprotein binding
GO_0035250Molecular functionUDP-galactosyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameB4GALT4
Protein nameBeta-1,4-galactosyltransferase 4
Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Lactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4)
Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)
SynonymshCG_22565
UNQ552/PRO1109
DescriptionFUNCTION: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids . Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer . Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration . In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide . .

FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .

FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .

AccessionsE7ETS9
ENST00000471675.1
ENST00000467604.5
B2RAZ5
ENST00000473887.5
ENST00000393765.7
ENST00000493932.5
C9J3R8
ENST00000470111.5
ENST00000483209.5
ENST00000479150.5
ENST00000491906.5
ENST00000475803.5
C9JY35
C9J5S0
ENST00000359213.7
C9JY38
O60513
ENST00000480814.5
C9JE00
C9JA31
C9J644
C9J4S5