B3GNT5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0006493Biological processprotein O-linked glycosylation
GO_0009247Biological processglycolipid biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0007417Biological processcentral nervous system development
GO_0000139Cellular componentGolgi membrane
GO_0008499Molecular functionUDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008532Molecular functionN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO_0047256Molecular functionlactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity

IV. Literature review

[source]
Gene nameB3GNT5
Protein nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)
Synonyms
DescriptionFUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. .

AccessionsENST00000326505.4
ENST00000465010.1
ENST00000464923.1
C9IYY0
Q9BYG0
C9J368
C9J5K2
ENST00000464191.1
ENST00000481531.1
ENST00000460419.1