Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 6 studies | 25% ± 5% | |
| microglial cell | 4 studies | 33% ± 4% | |
| GABAergic neuron | 3 studies | 39% ± 5% | |
| astrocyte | 3 studies | 18% ± 2% | |
| glutamatergic neuron | 3 studies | 53% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 40% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 2111.73 | 2642 / 2642 | 100% | 9.49 | 704 / 705 |
| thymus | 99% | 725.15 | 648 / 653 | 98% | 4.18 | 593 / 605 |
| prostate | 99% | 687.91 | 243 / 245 | 97% | 2.65 | 486 / 502 |
| kidney | 99% | 536.26 | 88 / 89 | 88% | 2.60 | 793 / 901 |
| adrenal gland | 99% | 797.74 | 256 / 258 | 87% | 2.91 | 199 / 230 |
| skin | 87% | 366.41 | 1577 / 1809 | 97% | 4.66 | 460 / 472 |
| breast | 84% | 530.64 | 387 / 459 | 97% | 4.21 | 1084 / 1118 |
| ovary | 99% | 1029.64 | 178 / 180 | 73% | 1.50 | 315 / 430 |
| uterus | 99% | 818.91 | 169 / 170 | 63% | 1.59 | 287 / 459 |
| lung | 83% | 367.81 | 479 / 578 | 76% | 2.22 | 882 / 1155 |
| intestine | 92% | 665.00 | 885 / 966 | 63% | 1.41 | 331 / 527 |
| bladder | 81% | 317.90 | 17 / 21 | 60% | 1.39 | 303 / 504 |
| pancreas | 35% | 103.41 | 115 / 328 | 93% | 3.41 | 166 / 178 |
| stomach | 43% | 138.92 | 154 / 359 | 53% | 1.05 | 153 / 286 |
| spleen | 95% | 365.98 | 228 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 56% | 227.19 | 804 / 1445 | 37% | 0.64 | 67 / 183 |
| eye | 0% | 0 | 0 / 0 | 80% | 1.88 | 64 / 80 |
| heart | 77% | 450.50 | 665 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 2.27 | 33 / 45 |
| adipose | 69% | 282.02 | 830 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 66% | 249.34 | 881 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 0.96 | 15 / 29 |
| muscle | 29% | 91.87 | 235 / 803 | 0% | 0 | 0 / 0 |
| liver | 12% | 30.26 | 27 / 226 | 16% | 0.31 | 66 / 406 |
| peripheral blood | 11% | 32.57 | 103 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042177 | Biological process | negative regulation of protein catabolic process |
| GO_0007283 | Biological process | spermatogenesis |
| GO_1902269 | Biological process | positive regulation of polyamine transmembrane transport |
| GO_0033387 | Biological process | putrescine biosynthetic process from ornithine |
| GO_0043085 | Biological process | positive regulation of catalytic activity |
| GO_0098629 | Biological process | trans-Golgi network membrane organization |
| GO_0097055 | Biological process | agmatine biosynthetic process |
| GO_1990005 | Cellular component | granular vesicle |
| GO_0005801 | Cellular component | cis-Golgi network |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0043204 | Cellular component | perikaryon |
| GO_0030425 | Cellular component | dendrite |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030133 | Cellular component | transport vesicle |
| GO_0030424 | Cellular component | axon |
| GO_0005634 | Cellular component | nucleus |
| GO_0008792 | Molecular function | arginine decarboxylase activity |
| GO_0042978 | Molecular function | ornithine decarboxylase activator activity |
| GO_0004586 | Molecular function | ornithine decarboxylase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AZIN2 |
| Protein name | Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p) Antizyme inhibitor 2 Arginine decarboxylase, isoform CRA_l (cDNA FLJ16166 fis, clone BRHIP2002143, highly similar to Arginine decarboxylase) |
| Synonyms | ADC ODCP KIAA1945 hCG_39685 |
| Description | FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding . Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production . Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking . . |
| Accessions | B3KV62 ENST00000652171.1 ENST00000294517.11 [Q96A70-1] Q96A70 ENST00000373441.1 [Q96A70-2] A0A494BZU1 ENST00000373443.7 [Q96A70-1] |
