AUNIP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AUNIP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AUNIP at tissue level.

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0007051Biological processspindle organization
GO_0005813Cellular componentcentrosome
GO_0090734Cellular componentsite of DNA damage
GO_0005737Cellular componentcytoplasm
GO_0000922Cellular componentspindle pole
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameAUNIP
Protein nameAurora kinase A- and ninein-interacting protein (AIBp)
SynonymsC1orf135
DescriptionFUNCTION: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination . Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair . Inhibits non-homologous end joining (NHEJ) . Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle . .

AccessionsQ9H7T9
ENST00000374298.4 [Q9H7T9-1]
ENST00000538789.5 [Q9H7T9-2]