I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 8% |
Insufficient scRNA-seq data for expression of ATXN7L3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4758.03 | 1445 / 1445 | 100% | 52.67 | 183 / 183 |
| prostate | 100% | 4650.17 | 245 / 245 | 100% | 39.33 | 502 / 502 |
| stomach | 100% | 3505.87 | 359 / 359 | 100% | 44.58 | 286 / 286 |
| brain | 100% | 7571.01 | 2639 / 2642 | 100% | 50.56 | 705 / 705 |
| lung | 100% | 4285.48 | 578 / 578 | 100% | 53.77 | 1153 / 1155 |
| skin | 100% | 4861.29 | 1809 / 1809 | 100% | 49.28 | 471 / 472 |
| breast | 100% | 3648.16 | 459 / 459 | 100% | 51.96 | 1115 / 1118 |
| bladder | 100% | 4076.62 | 21 / 21 | 100% | 57.26 | 502 / 504 |
| ovary | 100% | 3916.39 | 180 / 180 | 100% | 41.47 | 428 / 430 |
| thymus | 100% | 5095.07 | 653 / 653 | 100% | 47.74 | 602 / 605 |
| intestine | 100% | 4329.22 | 966 / 966 | 99% | 46.68 | 524 / 527 |
| uterus | 100% | 4765.62 | 170 / 170 | 99% | 56.84 | 456 / 459 |
| kidney | 100% | 3713.08 | 89 / 89 | 99% | 32.32 | 891 / 901 |
| pancreas | 99% | 2139.26 | 326 / 328 | 99% | 47.70 | 177 / 178 |
| adrenal gland | 100% | 3724.39 | 258 / 258 | 98% | 35.23 | 225 / 230 |
| liver | 100% | 2318.59 | 226 / 226 | 94% | 25.87 | 383 / 406 |
| adipose | 100% | 3634.15 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 41.27 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 50.72 | 29 / 29 |
| spleen | 100% | 5969.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 53.39 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 38.96 | 1 / 1 |
| blood vessel | 100% | 3484.97 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2272.45 | 849 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 5561.76 | 912 / 929 | 0% | 0 | 0 / 0 |
| muscle | 98% | 2225.12 | 786 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0043484 | Biological process | regulation of RNA splicing |
| GO_0006282 | Biological process | regulation of DNA repair |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0033276 | Cellular component | transcription factor TFTC complex |
| GO_0071819 | Cellular component | DUBm complex |
| GO_0000124 | Cellular component | SAGA complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0030374 | Molecular function | nuclear receptor coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | ATXN7L3 |
| Protein name | Alternative protein ATXN7L3 Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) Ataxin-7-like protein 3 Ataxin 7 like 3 SAGA-associated factor 11 |
| Synonyms | |
| Description | FUNCTION: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B . The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex . Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B . . FUNCTION: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. . FUNCTION: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. . |
| Accessions | ENST00000589805.1 ENST00000587097.6 [Q14CW9-1] K7ENZ2 L8E8Y9 K7EKG9 ENST00000587097 ENST00000591295.5 K7ENU1 Q14CW9 K7EMZ3 ENST00000389384.8 [Q14CW9-1] ENST00000590537.5 K7EJK2 ENST00000590169.5 ENST00000454077.6 [Q14CW9-2] |
