I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 26% ± 8% | |
| GABAergic neuron | 3 studies | 36% ± 3% | |
| glutamatergic neuron | 3 studies | 40% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 26% ± 8% | |
| GABAergic neuron | 3 studies | 36% ± 3% | |
| glutamatergic neuron | 3 studies | 40% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 26% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 100% | 933.33 | 965 / 966 | 96% | 6.98 | 508 / 527 |
| stomach | 100% | 803.13 | 359 / 359 | 95% | 7.66 | 271 / 286 |
| prostate | 99% | 717.06 | 243 / 245 | 95% | 4.49 | 475 / 502 |
| kidney | 100% | 663.43 | 89 / 89 | 89% | 3.41 | 798 / 901 |
| ovary | 100% | 748.00 | 180 / 180 | 87% | 3.61 | 376 / 430 |
| liver | 100% | 2141.47 | 226 / 226 | 87% | 3.66 | 354 / 406 |
| breast | 100% | 761.51 | 458 / 459 | 87% | 6.01 | 974 / 1118 |
| brain | 99% | 875.54 | 2608 / 2642 | 75% | 1.41 | 530 / 705 |
| pancreas | 96% | 399.45 | 315 / 328 | 78% | 3.27 | 138 / 178 |
| esophagus | 96% | 439.74 | 1391 / 1445 | 70% | 4.70 | 128 / 183 |
| skin | 98% | 433.75 | 1780 / 1809 | 67% | 1.69 | 318 / 472 |
| bladder | 100% | 610.00 | 21 / 21 | 58% | 2.75 | 292 / 504 |
| lung | 99% | 607.77 | 571 / 578 | 59% | 2.22 | 677 / 1155 |
| uterus | 100% | 807.94 | 170 / 170 | 44% | 2.51 | 201 / 459 |
| adrenal gland | 97% | 365.66 | 250 / 258 | 33% | 0.57 | 77 / 230 |
| thymus | 100% | 556.29 | 650 / 653 | 16% | 0.28 | 99 / 605 |
| adipose | 100% | 1066.37 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 568.35 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 547.12 | 852 / 861 | 0% | 0 | 0 / 0 |
| spleen | 93% | 255.58 | 223 / 241 | 0% | 0 | 0 / 0 |
| muscle | 91% | 236.81 | 727 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 31% | 0.49 | 25 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.37 | 7 / 45 |
| peripheral blood | 12% | 25.40 | 114 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.07 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015677 | Biological process | copper ion import |
| GO_0051208 | Biological process | sequestering of calcium ion |
| GO_0060003 | Biological process | copper ion export |
| GO_0006825 | Biological process | copper ion transport |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_1990961 | Biological process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0015680 | Biological process | protein maturation by copper ion transfer |
| GO_0006882 | Biological process | intracellular zinc ion homeostasis |
| GO_0046688 | Biological process | response to copper ion |
| GO_0007595 | Biological process | lactation |
| GO_0006878 | Biological process | intracellular copper ion homeostasis |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0032588 | Cellular component | trans-Golgi network membrane |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005770 | Cellular component | late endosome |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005375 | Molecular function | copper ion transmembrane transporter activity |
| GO_0043682 | Molecular function | P-type divalent copper transporter activity |
| GO_0140581 | Molecular function | P-type monovalent copper transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ATP7B |
| Protein name | ATPase Cu++ transporting beta polypeptide (EC 3.6.3.4) P-type Cu(+) transporter (EC 7.2.2.8) ATPase Cu++ transporting beta polypeptide ATPase 7B ATP7B protein Mutant ATP7B Cu++ transporting ATPase beta polypeptide ATP7B (EC 3.6.3.4) Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] Copper-transporting protein ATP7B (EC 3.6.3.54) ATPase copper transporting beta ATP7B ATPase Cu++ transporting beta polypeptide variant (EC 3.6.3.4) |
| Synonyms | PWD WC1 WND |
| Description | FUNCTION: Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. . |
| Accessions | A0A0U1RRG1 B7ZLR4 G1FFF1 Q9HBD7 ENST00000634308.1 ENST00000673864.2 A0A7G8LSD6 B7ZLR3 ENST00000448424.7 A0A2Z5ENX9 A0A7G8LS84 Q9HBD6 G1FFF2 ENST00000634296.2 Q52RG5 A0A2Z5ENX0 ENST00000400370.8 A0A2Z5ENX2 A0A2Z5ENX4 C0LF55 Q52RG4 A0A2Z5ENY1 ENST00000674147.1 A0A7G8LSD4 F5H748 ENST00000673772.1 ENST00000674147.2 [P35670-2] A0A2Z5ENW8 A0A7G8LS82 A0A0U1RQY8 D3KCZ0 A1YIY1 Q9HBD8 G1FFE8 G8FXH4 A6YQZ0 Q9GZP5 ENST00000418097.7 E7ET55 A7UDR4 A0A669KA36 ENST00000634844.1 A0A669KB88 G1FFF0 P35670 ENST00000400366.6 [P35670-3] A6N865 Q52RG6 Q9HBD5 C8BMD5 A0A2Z5ENX7 ENST00000242839.10 [P35670-1] Q52RG3 A0A7G8LSA9 G1FFE9 A6YQZ1 F5H562 B7ZLR2 A0A7G8LSD8 G1FFF3 Q52RG2 Q17RT3 A0A669KB21 Q9HBD9 |
