ATP6V1C1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0016241Biological processregulation of macroautophagy
GO_1902495Cellular componenttransmembrane transporter complex
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0016469Cellular componentproton-transporting two-sector ATPase complex
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045177Cellular componentapical part of cell
GO_0005886Cellular componentplasma membrane
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0098850Cellular componentextrinsic component of synaptic vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V1C1
Protein nameV-type proton ATPase subunit C
V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)
SynonymsATP6C
VATC
ATP6D
hCG_14602
DescriptionFUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. .

FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. .

AccessionsENST00000518857.5
ENST00000518738.2
ENST00000521514.5
E7EV59
A0A024R9I0
ENST00000395862.7
P21283