ATP2B2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	14 studies	39% ± 18%	Explore
glutamatergic neuron	13 studies	63% ± 26%	Explore
GABAergic neuron	9 studies	57% ± 28%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 11%	Explore
interneuron	6 studies	51% ± 28%	Explore
retinal ganglion cell	6 studies	50% ± 13%	Explore
neuron	4 studies	42% ± 15%	Explore
granule cell	4 studies	51% ± 18%	Explore
amacrine cell	4 studies	33% ± 13%	Explore
retina horizontal cell	4 studies	32% ± 7%	Explore
hepatocyte	4 studies	37% ± 11%	Explore
retinal bipolar neuron	3 studies	20% ± 5%	Explore
GABAergic interneuron	3 studies	52% ± 6%	Explore
OFF-bipolar cell	3 studies	27% ± 6%	Explore
ON-bipolar cell	3 studies	31% ± 4%	Explore
rod bipolar cell	3 studies	19% ± 2%	Explore
ependymal cell	3 studies	34% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	43% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	16945.65	2553 / 2642	98%	33.29	693 / 705
liver	100%	5015.81	226 / 226	89%	20.57	362 / 406
ovary	0%	0	0 / 180	58%	4.05	248 / 430
adrenal gland	2%	49.99	6 / 258	53%	6.92	121 / 230
kidney	0%	0	0 / 89	55%	4.70	492 / 901
muscle	46%	1270.31	369 / 803	0%	0	0 / 0
uterus	34%	517.26	58 / 170	7%	0.69	33 / 459
tonsil	0%	0	0 / 0	7%	0.39	3 / 45
breast	0%	3.72	1 / 459	6%	0.45	65 / 1118
thymus	0%	0	0 / 653	3%	0.14	18 / 605
pancreas	0%	0	0 / 328	3%	0.35	5 / 178
eye	0%	0	0 / 0	3%	0.27	2 / 80
skin	0%	0.46	1 / 1809	2%	0.23	11 / 472
esophagus	0%	1.07	2 / 1445	1%	0.07	2 / 183
intestine	0%	1.88	2 / 966	1%	0.13	5 / 527
lung	0%	0	0 / 578	1%	0.05	8 / 1155
bladder	0%	0	0 / 21	1%	0.06	3 / 504
spleen	0%	3.55	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
stomach	0%	0	0 / 359	0%	0	0 / 286
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0007605	Biological process	sensory perception of sound
GO_0099566	Biological process	regulation of postsynaptic cytosolic calcium ion concentration
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0003407	Biological process	neural retina development
GO_0030182	Biological process	neuron differentiation
GO_1903779	Biological process	regulation of cardiac conduction
GO_0006816	Biological process	calcium ion transport
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032809	Cellular component	neuronal cell body membrane
GO_0098982	Cellular component	GABA-ergic synapse
GO_0005737	Cellular component	cytoplasm
GO_0032591	Cellular component	dendritic spine membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0098688	Cellular component	parallel fiber to Purkinje cell synapse
GO_0016323	Cellular component	basolateral plasma membrane
GO_1905059	Molecular function	P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO_0005388	Molecular function	P-type calcium transporter activity
GO_0030165	Molecular function	PDZ domain binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0035254	Molecular function	glutamate receptor binding
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP2B2
Protein name	Calcium-transporting ATPase (EC 7.2.2.10) P-type Ca(2+) transporter (EC 7.2.2.10) PMCA2a PMCA2i Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) ATPase plasma membrane Ca2+ transporting 2 Alternative protein ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
Synonyms	PMCA2 protein variant
Description	FUNCTION: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems . Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment . Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance . In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia . In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels . In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). . FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium. . FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium. .
Accessions	ENST00000460129.5 [Q01814-4] A0A2U3U055 ENST00000352432.9 A1X4P9 ENST00000644553.1 ENST00000638646.2 ENST00000360273.7 [Q01814-1] ENST00000452124.2 [Q01814-8] A2VBC8 A0A2R8Y535 L0R6D2 A1X4P8 Q01814 A0A2U3TZI3 ENST00000467702.3 ENST00000643662.1 [Q01814-7] ENST00000644807.2 [Q01814-4] ENST00000397077.6 [Q01814-6] A0A2R8Y4R4 ENST00000646379.1 [Q01814-6] Q4LE63 ENST00000645850.1 [Q01814-1]

ATP2B2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review