ATG2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000422Biological processautophagy of mitochondrion
GO_0120009Biological processintermembrane lipid transfer
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0061709Biological processreticulophagy
GO_0030242Biological processautophagy of peroxisome
GO_0061723Biological processglycophagy
GO_0000045Biological processautophagosome assembly
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005811Cellular componentlipid droplet
GO_0000407Cellular componentphagophore assembly site
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061908Cellular componentphagophore
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0120013Molecular functionlipid transfer activity
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding

IV. Literature review

[source]
Gene nameATG2B
Protein nameAutophagy-related protein 2 homolog B
Alternative protein ATG2B
SynonymsC14orf103
DescriptionFUNCTION: Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion . Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion . Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . .

AccessionsL8E8U7
ENST00000359933.6
Q96BY7