Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD16-negative, CD56-bright natural killer cell, human | 5 studies | 21% ± 6% | |
| natural killer cell | 4 studies | 25% ± 9% | |
| epithelial cell | 4 studies | 19% ± 4% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 33% ± 11% | |
| classical monocyte | 3 studies | 19% ± 3% | |
| CD8-positive, alpha-beta memory T cell | 3 studies | 22% ± 4% | |
| gamma-delta T cell | 3 studies | 20% ± 1% |
Insufficient scRNA-seq data for expression of ATG2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2922.04 | 1445 / 1445 | 100% | 32.26 | 183 / 183 |
| thymus | 100% | 3940.22 | 653 / 653 | 100% | 23.06 | 604 / 605 |
| liver | 100% | 4402.34 | 226 / 226 | 100% | 18.27 | 405 / 406 |
| intestine | 100% | 3521.48 | 966 / 966 | 100% | 22.73 | 525 / 527 |
| uterus | 100% | 4034.31 | 170 / 170 | 100% | 18.38 | 457 / 459 |
| prostate | 100% | 3891.06 | 245 / 245 | 99% | 21.40 | 499 / 502 |
| skin | 100% | 4783.89 | 1809 / 1809 | 99% | 27.59 | 469 / 472 |
| ovary | 100% | 4646.38 | 180 / 180 | 99% | 24.32 | 427 / 430 |
| pancreas | 100% | 2182.41 | 327 / 328 | 99% | 19.20 | 177 / 178 |
| stomach | 100% | 3261.51 | 359 / 359 | 99% | 24.49 | 283 / 286 |
| kidney | 100% | 3004.43 | 89 / 89 | 99% | 15.78 | 890 / 901 |
| bladder | 100% | 3293.14 | 21 / 21 | 99% | 18.97 | 497 / 504 |
| lung | 100% | 4453.07 | 578 / 578 | 98% | 20.60 | 1136 / 1155 |
| brain | 99% | 2576.77 | 2605 / 2642 | 100% | 24.72 | 703 / 705 |
| breast | 100% | 3453.76 | 459 / 459 | 98% | 18.07 | 1099 / 1118 |
| adrenal gland | 100% | 3342.50 | 258 / 258 | 98% | 17.02 | 226 / 230 |
| adipose | 100% | 3078.56 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 46.39 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 19.05 | 29 / 29 |
| spleen | 100% | 4178.68 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 22.15 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.01 | 1 / 1 |
| blood vessel | 100% | 2730.36 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 3267.35 | 802 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 6999.31 | 925 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 1908.44 | 833 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000422 | Biological process | autophagy of mitochondrion |
| GO_0120009 | Biological process | intermembrane lipid transfer |
| GO_0034727 | Biological process | piecemeal microautophagy of the nucleus |
| GO_0061709 | Biological process | reticulophagy |
| GO_2000786 | Biological process | positive regulation of autophagosome assembly |
| GO_0030242 | Biological process | autophagy of peroxisome |
| GO_0061723 | Biological process | glycophagy |
| GO_0000045 | Biological process | autophagosome assembly |
| GO_0034045 | Cellular component | phagophore assembly site membrane |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0044232 | Cellular component | organelle membrane contact site |
| GO_0000407 | Cellular component | phagophore assembly site |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0061908 | Cellular component | phagophore |
| GO_0043495 | Molecular function | protein-membrane adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0120013 | Molecular function | lipid transfer activity |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| Gene name | ATG2A |
| Protein name | Autophagy-related protein 2 homolog A Autophagy related 2A ATG2A protein |
| Synonyms | KIAA0404 |
| Description | FUNCTION: Lipid transfer protein involved in autophagosome assembly . Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion . Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion . Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Also regulates lipid droplets morphology and distribution within the cell . . |
| Accessions | ENST00000418259.5 H7C3T2 ENST00000377264.8 [Q2TAZ0-1] A0AUL9 Q2TAZ0 |
