ATG14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0006622Biological processprotein targeting to lysosome
GO_0000045Biological processautophagosome assembly
GO_0061635Biological processregulation of protein complex stability
GO_0016236Biological processmacroautophagy
GO_0001932Biological processregulation of protein phosphorylation
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0009267Biological processcellular response to starvation
GO_0016240Biological processautophagosome membrane docking
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0090207Biological processregulation of triglyceride metabolic process
GO_0008333Biological processendosome to lysosome transport
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0000423Biological processmitophagy
GO_0016241Biological processregulation of macroautophagy
GO_0045022Biological processearly endosome to late endosome transport
GO_0097352Biological processautophagosome maturation
GO_0098780Biological processresponse to mitochondrial depolarisation
GO_0097629Cellular componentextrinsic component of omegasome membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0035032Cellular componentphosphatidylinositol 3-kinase complex, class III
GO_0000421Cellular componentautophagosome membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005930Cellular componentaxoneme
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0097632Cellular componentextrinsic component of phagophore assembly site membrane
GO_0035014Molecular functionphosphatidylinositol 3-kinase regulator activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0051020Molecular functionGTPase binding
GO_0141039Molecular functionphosphatidylinositol 3-kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG14
Protein nameBeclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)
SynonymsATG14L
KIAA0831
DescriptionFUNCTION: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 . Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine . Promotes BECN1 translocation from the trans-Golgi network to autophagosomes . Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 . Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK . Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion . Modulates the hepatic lipid metabolism (By similarity). .

AccessionsENST00000247178.6 [Q6ZNE5-1]
Q6ZNE5