ATG13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_1903059Biological processregulation of protein lipidation
GO_0000045Biological processautophagosome assembly
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0010508Biological processpositive regulation of autophagy
GO_0000423Biological processmitophagy
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0098780Biological processresponse to mitochondrial depolarisation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005829Cellular componentcytosol
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0019887Molecular functionprotein kinase regulator activity
GO_0019901Molecular functionprotein kinase binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG13
Protein nameAutophagy-related protein 13
Autophagy related 13
SynonymsKIAA0652
DescriptionFUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. .

AccessionsJ3QRL1
ENST00000395549.3
A0A1B0GXJ3
H0YCL5
ENST00000525009.5
ENST00000581438.5
J3QR83
ENST00000532067.1
ENST00000582547.5
ENST00000580238.5
ENST00000528494.5 [O75143-5]
J3QLH7
J3KRU6
ENST00000529395.1
ENST00000524625.5 [O75143-2]
H0YEM7
ENST00000359513.8 [O75143-1]
J3QR16
ENST00000583249.5
H0YDR0
ENST00000530500.5 [O75143-4]
ENST00000578626.5
ENST00000529655.5 [O75143-2]
ENST00000581416.5
H0YF43
O75143
J9JIF6
ENST00000683050.1 [O75143-5]
ENST00000533325.5
E9PPR2
ENST00000531933.1
ENST00000526508.5 [O75143-1]
J3KST9
ENST00000577256.5