ATAD5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902751Biological processpositive regulation of cell cycle G2/M phase transition
GO_0090618Biological processDNA clamp unloading
GO_0008283Biological processcell population proliferation
GO_0033260Biological processnuclear DNA replication
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0045740Biological processpositive regulation of DNA replication
GO_0048304Biological processpositive regulation of isotype switching to IgG isotypes
GO_0030890Biological processpositive regulation of B cell proliferation
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0045190Biological processisotype switching
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0031391Cellular componentElg1 RFC-like complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061860Molecular functionDNA clamp unloader activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATAD5
Protein nameATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
ATPase family AAA domain containing 5
SynonymsC17orf41
Elg1
FRAG1
DescriptionFUNCTION: Has an important role in DNA replication and in maintaining genome integrity during replication stress . Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis . Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis . Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway . As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle . This seems to be dependent on its ATPase activity . Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner . Ultimately this enables replication fork regression, breakage, and eventual fork restart . Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks . Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks . .

AccessionsENST00000321990.5 [Q96QE3-1]
A0A075B754
Q96QE3
ENST00000578295.5