Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 26% ± 8% | |
astrocyte | 8 studies | 31% ± 12% | |
glutamatergic neuron | 7 studies | 45% ± 27% | |
GABAergic neuron | 7 studies | 42% ± 20% | |
epithelial cell | 6 studies | 33% ± 11% | |
pericyte | 5 studies | 20% ± 3% | |
retinal rod cell | 5 studies | 23% ± 5% | |
fibroblast | 5 studies | 22% ± 5% | |
cardiac muscle cell | 5 studies | 24% ± 4% | |
oligodendrocyte precursor cell | 5 studies | 30% ± 10% | |
interneuron | 5 studies | 41% ± 22% | |
oligodendrocyte | 5 studies | 25% ± 8% | |
neuron | 4 studies | 34% ± 7% | |
microglial cell | 4 studies | 21% ± 3% | |
retina horizontal cell | 4 studies | 27% ± 7% | |
ciliated cell | 4 studies | 23% ± 4% | |
Mueller cell | 4 studies | 25% ± 8% | |
type I pneumocyte | 4 studies | 19% ± 4% | |
GABAergic interneuron | 3 studies | 20% ± 4% | |
retinal ganglion cell | 3 studies | 38% ± 14% | |
retinal cone cell | 3 studies | 27% ± 3% | |
adipocyte | 3 studies | 18% ± 2% | |
lymphocyte | 3 studies | 20% ± 4% | |
rod bipolar cell | 3 studies | 24% ± 3% | |
dendritic cell | 3 studies | 21% ± 3% | |
basal cell | 3 studies | 32% ± 3% | |
goblet cell | 3 studies | 24% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 2747.78 | 653 / 653 | 100% | 35.64 | 603 / 605 |
brain | 100% | 2978.57 | 2640 / 2642 | 100% | 43.40 | 702 / 705 |
kidney | 100% | 1973.91 | 89 / 89 | 99% | 33.37 | 894 / 901 |
adrenal gland | 100% | 2829.65 | 258 / 258 | 99% | 44.53 | 228 / 230 |
esophagus | 100% | 2556.09 | 1445 / 1445 | 99% | 38.34 | 181 / 183 |
pancreas | 99% | 1302.40 | 326 / 328 | 99% | 33.97 | 177 / 178 |
breast | 100% | 2834.08 | 459 / 459 | 99% | 42.96 | 1104 / 1118 |
liver | 100% | 1544.77 | 226 / 226 | 99% | 19.43 | 400 / 406 |
lung | 100% | 2603.91 | 577 / 578 | 98% | 34.88 | 1136 / 1155 |
bladder | 100% | 2658.00 | 21 / 21 | 98% | 31.31 | 494 / 504 |
intestine | 100% | 2825.38 | 966 / 966 | 98% | 33.12 | 515 / 527 |
ovary | 100% | 2652.67 | 180 / 180 | 98% | 28.25 | 420 / 430 |
uterus | 100% | 2962.93 | 170 / 170 | 98% | 32.05 | 448 / 459 |
prostate | 100% | 2803.91 | 245 / 245 | 97% | 39.57 | 489 / 502 |
stomach | 100% | 1925.49 | 359 / 359 | 97% | 32.14 | 277 / 286 |
skin | 100% | 2803.50 | 1807 / 1809 | 93% | 37.27 | 441 / 472 |
blood vessel | 100% | 3201.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.55 | 29 / 29 |
muscle | 100% | 3540.35 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1770.26 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.85 | 1 / 1 |
adipose | 100% | 2680.12 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 98% | 3954.81 | 846 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 36.76 | 78 / 80 |
tonsil | 0% | 0 | 0 / 0 | 96% | 27.32 | 43 / 45 |
peripheral blood | 54% | 1591.36 | 498 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007613 | Biological process | memory |
GO_0140570 | Biological process | extraction of mislocalized protein from mitochondrial outer membrane |
GO_0007612 | Biological process | learning |
GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
GO_0002092 | Biological process | positive regulation of receptor internalization |
GO_0051967 | Biological process | negative regulation of synaptic transmission, glutamatergic |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0045211 | Cellular component | postsynaptic membrane |
GO_0140567 | Molecular function | membrane protein dislocase activity |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | ATAD1 |
Protein name | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) ATPase family AAA domain containing 1 Outer mitochondrial transmembrane helix translocase ATPase family AAA domain containing 1 (ATPase family, AAA domain containing 1, isoform CRA_b) |
Synonyms | FNP001 hCG_23332 |
Description | FUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria . Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). . |
Accessions | A0A7P0TAM5 ENST00000308448.11 [Q8NBU5-1] ENST00000680388.1 A0A7P0T9U2 Q8NBU5 A0A7P0T9B4 ENST00000681602.1 ENST00000328142.3 [Q8NBU5-1] A0A7P0T7Z9 ENST00000681308.1 ENST00000495903.1 ENST00000681629.1 A0A7P0Z4J1 ENST00000680024.1 [Q8NBU5-1] |