ATAD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007613Biological processmemory
GO_0140570Biological processextraction of mislocalized protein from mitochondrial outer membrane
GO_0007612Biological processlearning
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0002092Biological processpositive regulation of receptor internalization
GO_0051967Biological processnegative regulation of synaptic transmission, glutamatergic
GO_0005778Cellular componentperoxisomal membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0140567Molecular functionmembrane protein dislocase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameATAD1
Protein nameOuter mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase)
ATPase family AAA domain containing 1
Outer mitochondrial transmembrane helix translocase
ATPase family AAA domain containing 1 (ATPase family, AAA domain containing 1, isoform CRA_b)
SynonymsFNP001
hCG_23332
DescriptionFUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria . Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). .

AccessionsA0A7P0TAM5
ENST00000308448.11 [Q8NBU5-1]
ENST00000680388.1
A0A7P0T9U2
Q8NBU5
A0A7P0T9B4
ENST00000681602.1
ENST00000328142.3 [Q8NBU5-1]
A0A7P0T7Z9
ENST00000681308.1
ENST00000495903.1
ENST00000681629.1
A0A7P0Z4J1
ENST00000680024.1 [Q8NBU5-1]