ASZ1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ASZ1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASZ1 at tissue level.

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0007140Biological processmale meiotic nuclear division
GO_0071546Cellular componentpi-body
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASZ1
Protein nameAnkyrin repeat, SAM and basic leucine zipper domain containing 1
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Ankyrin-like protein 1) (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)
SynonymsALP1
hCG_15953
ANKL1
C7orf7
GASZ
DescriptionFUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). .

FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. .

AccessionsENST00000284629.7 [Q8WWH4-1]
Q49AP3
C9JP59
F8WDQ2
ENST00000428663.1
Q8WWH4
ENST00000450714.2