ASIC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071467Biological processcellular response to pH
GO_0042391Biological processregulation of membrane potential
GO_0007269Biological processneurotransmitter secretion
GO_0008306Biological processassociative learning
GO_0070207Biological processprotein homotrimerization
GO_0046929Biological processnegative regulation of neurotransmitter secretion
GO_0050915Biological processsensory perception of sour taste
GO_0010447Biological processresponse to acidic pH
GO_0006814Biological processsodium ion transport
GO_0001662Biological processbehavioral fear response
GO_0007613Biological processmemory
GO_0001975Biological processresponse to amphetamine
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0009986Cellular componentcell surface
GO_0160128Molecular functionpH-gated monoatomic ion channel activity
GO_0015280Molecular functionligand-gated sodium channel activity
GO_0022839Molecular functionmonoatomic ion-gated channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASIC1
Protein nameAcid sensing ion channel subunit 1
Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
SynonymsBNAC2
ACCN2
DescriptionFUNCTION: Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. .; FUNCTION: Isoform 1 does not display proton-gated cation channel activity. .

AccessionsENST00000552633.2
ENST00000228468.8 [P78348-1]
P78348
ENST00000550558.5
H7C1W9
ENST00000453327.7
F8VSK4
ENST00000552438.5 [P78348-3]
H0YHD6
ENST00000447966.7 [P78348-2]