ASCC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006307Biological processDNA alkylation repair
GO_1990116Biological processribosome-associated ubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0006355Biological processregulation of DNA-templated transcription
GO_0032790Biological processribosome disassembly
GO_0016607Cellular componentnuclear speck
GO_0022626Cellular componentcytosolic ribosome
GO_0005654Cellular componentnucleoplasm
GO_0099053Cellular componentactivating signal cointegrator 1 complex
GO_1990391Cellular componentDNA repair complex
GO_0005634Cellular componentnucleus
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameASCC2
Protein nameActivating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)
Activating signal cointegrator 1 complex subunit 2
SynonymsRQT3
ASC1P100
DescriptionFUNCTION: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes . Plays a role in DNA damage repair as component of the ASCC complex . Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation . Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation . Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes . .

AccessionsENST00000307790.8 [Q9H1I8-1]
ENST00000454854.5
Q9H1I8
F2Z2W4
H7C3Y4
ENST00000411532.1
ENST00000453160.5
ENST00000542393.5 [Q9H1I8-3]
ENST00000458594.5
ENST00000431535.5
B1AH59
H7C395
ENST00000397771.6 [Q9H1I8-1]