Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 6 studies | 21% ± 5% | |
epithelial cell | 5 studies | 29% ± 7% | |
macrophage | 5 studies | 20% ± 2% | |
natural killer cell | 4 studies | 18% ± 2% | |
astrocyte | 4 studies | 22% ± 6% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 1% | |
conventional dendritic cell | 3 studies | 29% ± 11% | |
non-classical monocyte | 3 studies | 27% ± 8% | |
squamous epithelial cell | 3 studies | 27% ± 13% | |
adipocyte | 3 studies | 21% ± 4% | |
GABAergic neuron | 3 studies | 28% ± 9% | |
glutamatergic neuron | 3 studies | 34% ± 11% | |
microglial cell | 3 studies | 23% ± 5% | |
erythrocyte | 3 studies | 26% ± 10% | |
abnormal cell | 3 studies | 17% ± 3% | |
basal cell | 3 studies | 30% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 3624.59 | 226 / 226 | 100% | 39.58 | 406 / 406 |
pancreas | 100% | 2382.89 | 328 / 328 | 100% | 47.68 | 178 / 178 |
prostate | 100% | 4651.32 | 245 / 245 | 100% | 50.99 | 502 / 502 |
skin | 100% | 4397.77 | 1809 / 1809 | 100% | 59.21 | 472 / 472 |
stomach | 100% | 3661.69 | 359 / 359 | 100% | 35.84 | 286 / 286 |
thymus | 100% | 4878.53 | 653 / 653 | 100% | 51.89 | 605 / 605 |
uterus | 100% | 3265.21 | 170 / 170 | 100% | 58.09 | 459 / 459 |
esophagus | 100% | 4281.97 | 1444 / 1445 | 100% | 43.42 | 183 / 183 |
lung | 100% | 3640.66 | 578 / 578 | 100% | 52.82 | 1153 / 1155 |
intestine | 100% | 3361.94 | 966 / 966 | 100% | 38.11 | 526 / 527 |
ovary | 100% | 2898.97 | 180 / 180 | 100% | 33.99 | 429 / 430 |
kidney | 100% | 3146.55 | 89 / 89 | 100% | 34.94 | 898 / 901 |
bladder | 100% | 4116.14 | 21 / 21 | 100% | 80.01 | 502 / 504 |
breast | 100% | 4093.54 | 459 / 459 | 100% | 45.17 | 1113 / 1118 |
adrenal gland | 100% | 4988.09 | 258 / 258 | 99% | 34.57 | 228 / 230 |
brain | 99% | 1595.00 | 2612 / 2642 | 100% | 35.88 | 705 / 705 |
adipose | 100% | 4151.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 54.86 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 52.72 | 29 / 29 |
muscle | 100% | 3672.33 | 803 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 6926.39 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 4655.20 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 53.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 65.22 | 1 / 1 |
blood vessel | 100% | 2719.67 | 1332 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 2598.71 | 847 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032508 | Biological process | DNA duplex unwinding |
GO_0006307 | Biological process | DNA alkylation repair |
GO_1990116 | Biological process | ribosome-associated ubiquitin-dependent protein catabolic process |
GO_0072344 | Biological process | rescue of stalled ribosome |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0032790 | Biological process | ribosome disassembly |
GO_0016607 | Cellular component | nuclear speck |
GO_0022626 | Cellular component | cytosolic ribosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0099053 | Cellular component | activating signal cointegrator 1 complex |
GO_1990391 | Cellular component | DNA repair complex |
GO_0005634 | Cellular component | nucleus |
GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | ASCC2 |
Protein name | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) Activating signal cointegrator 1 complex subunit 2 |
Synonyms | RQT3 ASC1P100 |
Description | FUNCTION: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes . Plays a role in DNA damage repair as component of the ASCC complex . Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation . Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation . Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes . . |
Accessions | ENST00000307790.8 [Q9H1I8-1] ENST00000454854.5 Q9H1I8 F2Z2W4 H7C3Y4 ENST00000411532.1 ENST00000453160.5 ENST00000542393.5 [Q9H1I8-3] ENST00000458594.5 ENST00000431535.5 B1AH59 H7C395 ENST00000397771.6 [Q9H1I8-1] |