ARRDC4 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	24% ± 8%	Explore
alveolar macrophage	3 studies	21% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARRDC4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	2329.40	245 / 245	99%	24.02	497 / 502
thymus	100%	3554.97	652 / 653	99%	27.95	597 / 605
kidney	100%	4288.07	89 / 89	97%	43.22	871 / 901
breast	100%	1846.77	459 / 459	95%	23.60	1064 / 1118
pancreas	98%	2425.11	323 / 328	97%	34.81	172 / 178
intestine	100%	7045.13	966 / 966	94%	23.68	496 / 527
lung	99%	3218.26	574 / 578	93%	23.10	1076 / 1155
stomach	100%	4444.30	359 / 359	92%	23.22	262 / 286
brain	92%	2222.69	2430 / 2642	99%	50.75	701 / 705
esophagus	98%	4017.47	1410 / 1445	93%	33.14	170 / 183
uterus	100%	2579.52	170 / 170	89%	19.11	408 / 459
adrenal gland	98%	2389.91	253 / 258	90%	18.99	208 / 230
bladder	100%	3056.90	21 / 21	84%	16.34	422 / 504
skin	89%	3434.37	1615 / 1809	90%	35.85	427 / 472
liver	87%	1395.68	197 / 226	67%	15.13	272 / 406
ovary	91%	1383.79	163 / 180	56%	7.85	242 / 430
ureter	0%	0	0 / 0	100%	13.41	1 / 1
adipose	99%	1929.47	1190 / 1204	0%	0	0 / 0
spleen	99%	1627.84	238 / 241	0%	0	0 / 0
muscle	93%	1603.47	743 / 803	0%	0	0 / 0
heart	90%	1536.42	777 / 861	0%	0	0 / 0
blood vessel	89%	1269.48	1191 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	19.90	39 / 45
lymph node	0%	0	0 / 0	66%	9.56	19 / 29
eye	0%	0	0 / 0	50%	6.00	40 / 80
peripheral blood	35%	471.88	325 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0015031	Biological process	protein transport
GO_0016567	Biological process	protein ubiquitination
GO_0032728	Biological process	positive regulation of interferon-beta production
GO_0140112	Biological process	extracellular vesicle biogenesis
GO_0070534	Biological process	protein K63-linked ubiquitination
GO_0051443	Biological process	positive regulation of ubiquitin-protein transferase activity
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_1903561	Cellular component	extracellular vesicle
GO_0005768	Cellular component	endosome
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005769	Cellular component	early endosome
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0005515	Molecular function	protein binding

Gene name	ARRDC4
Protein name	Arrestin domain-containing protein 4
Synonyms
Description	FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake . Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 . .
Accessions	Q8NCT1 ENST00000268042.7

ARRDC4 report