ARRDC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006858Biological processextracellular transport
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0140112Biological processextracellular vesicle biogenesis
GO_0070062Cellular componentextracellular exosome
GO_1903561Cellular componentextracellular vesicle
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_1990763Molecular functionarrestin family protein binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARRDC1
Protein nameArrestin domain containing 1
Arrestin domain-containing protein 1 (Alpha-arrestin 1)
Synonyms
DescriptionFUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates . Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles . More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles . By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway . .

AccessionsENST00000431925.6
Q5T370
Q5T371
Q8N5I2
ENST00000461627.1
F2Z3I4
ENST00000371421.9
ENST00000419386.1