ARK2C | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	7 studies	41% ± 21%	Explore
amacrine cell	7 studies	26% ± 7%	Explore
interneuron	6 studies	41% ± 18%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 8%	Explore
retina horizontal cell	6 studies	28% ± 7%	Explore
GABAergic neuron	6 studies	42% ± 12%	Explore
neuron	4 studies	32% ± 10%	Explore
granule cell	3 studies	27% ± 4%	Explore
retinal cone cell	3 studies	29% ± 3%	Explore
GABAergic amacrine cell	3 studies	31% ± 3%	Explore
glycinergic amacrine cell	3 studies	24% ± 4%	Explore

Name	Number of supported studies	Average coverage
brain	7 studies	34% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	1753.53	2519 / 2642	93%	10.09	657 / 705
thymus	100%	675.90	652 / 653	85%	3.24	512 / 605
prostate	96%	755.95	236 / 245	43%	0.90	216 / 502
breast	76%	381.99	347 / 459	49%	1.25	546 / 1118
lung	73%	208.32	420 / 578	34%	1.25	392 / 1155
liver	98%	692.41	221 / 226	7%	0.11	27 / 406
spleen	100%	1767.63	241 / 241	0%	0	0 / 0
esophagus	61%	263.89	887 / 1445	34%	1.49	63 / 183
adrenal gland	19%	60.78	49 / 258	67%	4.37	154 / 230
uterus	24%	66.81	40 / 170	59%	2.07	271 / 459
tonsil	0%	0	0 / 0	73%	5.44	33 / 45
skin	65%	240.43	1173 / 1809	6%	0.21	26 / 472
kidney	24%	77.62	21 / 89	47%	1.36	420 / 901
adipose	63%	173.80	757 / 1204	0%	0	0 / 0
bladder	33%	91.38	7 / 21	23%	0.63	116 / 504
heart	48%	121.33	415 / 861	0%	0	0 / 0
intestine	44%	122.25	429 / 966	3%	0.07	14 / 527
ovary	3%	9.83	6 / 180	35%	0.75	151 / 430
peripheral blood	32%	103.25	293 / 929	0%	0	0 / 0
muscle	30%	90.23	238 / 803	0%	0	0 / 0
stomach	22%	57.51	80 / 359	5%	0.08	14 / 286
pancreas	1%	2.29	4 / 328	15%	0.31	27 / 178
blood vessel	12%	30.19	157 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.06	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0061061	Biological process	muscle structure development
GO_0008045	Biological process	motor neuron axon guidance
GO_0000209	Biological process	protein polyubiquitination
GO_0060384	Biological process	innervation
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0035136	Biological process	forelimb morphogenesis
GO_0030163	Biological process	protein catabolic process
GO_0032991	Cellular component	protein-containing complex
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	ARK2C
Protein name	Ring finger protein 165 E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)
Synonyms	RNF165
Description	FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. .
Accessions	ENST00000590330.1 ENST00000543885.2 [Q6ZSG1-2] ENST00000588679.1 ENST00000593230.5 K7EQ96 K7ELT0 ENST00000587853.1 ENST00000269439.12 [Q6ZSG1-1] K7EIS4 ENST00000586604.5 K7EPZ9 Q6ZSG1

ARK2C report