ARFIP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031529Biological processruffle organization
GO_0030032Biological processlamellipodium assembly
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0006886Biological processintracellular protein transport
GO_0030036Biological processactin cytoskeleton organization
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0000423Biological processmitophagy
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0001726Cellular componentruffle
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0019904Molecular functionprotein domain specific binding
GO_0005543Molecular functionphospholipid binding
GO_0045296Molecular functioncadherin binding
GO_0030742Molecular functionGTP-dependent protein binding
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005525Molecular functionGTP binding
GO_0140090Molecular functionmembrane curvature sensor activity
GO_0005515Molecular functionprotein binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding

IV. Literature review

[source]
Gene nameARFIP2
Protein nameArfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1)
ADP ribosylation factor interacting protein 2
SynonymsPOR1
DescriptionFUNCTION: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network . May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 . Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site . Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria . In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG . .

AccessionsENST00000396777.8 [P53365-1]
ENST00000445086.6 [P53365-2]
A0A087X1E4
P53365
ENST00000254584.6 [P53365-1]
ENST00000531037.5
ENST00000423813.6 [P53365-3]
E9PPY7
E9PRV8
ENST00000614314.4
ENST00000525235.1