AQP8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AQP8 at tissue level.

III. Associated gene sets

GO_0071918Biological processurea transmembrane transport
GO_0072489Biological processmethylammonium transmembrane transport
GO_0072488Biological processammonium transmembrane transport
GO_0015840Biological processurea transport
GO_0080170Biological processhydrogen peroxide transmembrane transport
GO_1990748Biological processcellular detoxification
GO_0140157Biological processammonium import across plasma membrane
GO_0006833Biological processwater transport
GO_0071320Biological processcellular response to cAMP
GO_0015843Biological processmethylammonium transport
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0030183Biological processB cell differentiation
GO_0035377Biological processtransepithelial water transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005790Cellular componentsmooth endoplasmic reticulum
GO_0031966Cellular componentmitochondrial membrane
GO_0097708Cellular componentintracellular vesicle
GO_0005743Cellular componentmitochondrial inner membrane
GO_0030868Cellular componentsmooth endoplasmic reticulum membrane
GO_0045177Cellular componentapical part of cell
GO_0046691Cellular componentintracellular canaliculus
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015265Molecular functionurea channel activity
GO_0015250Molecular functionwater channel activity
GO_0015264Molecular functionmethylammonium channel activity
GO_0008519Molecular functionammonium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAQP8
Protein nameAquaporin-8 (AQP-8)
Aquaporin 8 variant (Aquaporin 8, isoform CRA_b)
Aquaporin 8
SynonymshCG_21975
DescriptionFUNCTION: Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues . The transport of the ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (By similarity). However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (By similarity). Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion . Does not transport urea or glycerol . The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces . At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation . In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation . In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (By similarity). In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity). May play an important role in the adaptive response of proximal tubule cells to acidosis possibly by facilitating the mitochondrial ammonia transport . .

AccessionsO94778
ENST00000566125.5
ENST00000219660.6
A0A0C4DGL6
Q53GF6