Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 9 studies | 29% ± 15% | |
| endothelial cell | 8 studies | 22% ± 6% | |
| oligodendrocyte | 7 studies | 26% ± 8% | |
| epithelial cell | 6 studies | 29% ± 9% | |
| ciliated cell | 5 studies | 23% ± 6% | |
| glutamatergic neuron | 4 studies | 46% ± 18% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 9% | |
| interneuron | 4 studies | 37% ± 22% | |
| fibroblast | 3 studies | 22% ± 6% | |
| GABAergic neuron | 3 studies | 47% ± 3% | |
| dendritic cell | 3 studies | 19% ± 3% | |
| abnormal cell | 3 studies | 22% ± 8% | |
| ependymal cell | 3 studies | 27% ± 15% | |
| macrophage | 3 studies | 20% ± 3% | |
| basal cell | 3 studies | 32% ± 16% | |
| transit amplifying cell | 3 studies | 32% ± 23% | |
| adipocyte | 3 studies | 23% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1353.43 | 21 / 21 | 100% | 7.13 | 504 / 504 |
| esophagus | 100% | 1449.50 | 1445 / 1445 | 100% | 5.22 | 183 / 183 |
| intestine | 100% | 1297.48 | 966 / 966 | 100% | 6.45 | 527 / 527 |
| kidney | 100% | 1431.09 | 89 / 89 | 100% | 4.81 | 901 / 901 |
| liver | 100% | 1216.36 | 226 / 226 | 100% | 4.05 | 406 / 406 |
| lung | 100% | 1311.79 | 578 / 578 | 100% | 7.12 | 1155 / 1155 |
| ovary | 100% | 1253.67 | 180 / 180 | 100% | 4.08 | 430 / 430 |
| pancreas | 100% | 870.08 | 328 / 328 | 100% | 4.95 | 178 / 178 |
| prostate | 100% | 1710.06 | 245 / 245 | 100% | 7.22 | 502 / 502 |
| stomach | 100% | 1078.98 | 359 / 359 | 100% | 5.41 | 286 / 286 |
| thymus | 100% | 1237.14 | 653 / 653 | 100% | 5.23 | 605 / 605 |
| uterus | 100% | 1430.60 | 170 / 170 | 100% | 8.06 | 459 / 459 |
| brain | 100% | 1266.03 | 2641 / 2642 | 100% | 6.43 | 705 / 705 |
| breast | 100% | 1365.97 | 459 / 459 | 100% | 8.40 | 1117 / 1118 |
| skin | 100% | 1985.16 | 1809 / 1809 | 100% | 5.54 | 471 / 472 |
| adrenal gland | 100% | 2040.54 | 258 / 258 | 99% | 5.00 | 228 / 230 |
| adipose | 100% | 1256.93 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 4.78 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 8.03 | 29 / 29 |
| spleen | 100% | 1324.87 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 7.88 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.14 | 1 / 1 |
| blood vessel | 100% | 1086.52 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 716.86 | 794 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 785.71 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 85% | 828.10 | 790 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000012 | Biological process | single strand break repair |
| GO_0006266 | Biological process | DNA ligation |
| GO_0031647 | Biological process | regulation of protein stability |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0003697 | Molecular function | single-stranded DNA binding |
| GO_1990165 | Molecular function | single-strand break-containing DNA binding |
| GO_0003690 | Molecular function | double-stranded DNA binding |
| GO_0030983 | Molecular function | mismatched DNA binding |
| GO_0008967 | Molecular function | phosphoglycolate phosphatase activity |
| GO_0120108 | Molecular function | DNA-3'-diphospho-5'-guanosine diphosphatase |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0033699 | Molecular function | DNA 5'-adenosine monophosphate hydrolase activity |
| GO_0051219 | Molecular function | phosphoprotein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003684 | Molecular function | damaged DNA binding |
| GO_0003725 | Molecular function | double-stranded RNA binding |
| Gene name | APTX |
| Protein name | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) Aprataxin Aprataxin (Aprataxin variant LP3E5) Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) |
| Synonyms | AXA1 |
| Description | FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair . Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species . Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined . Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity . Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). . |
| Accessions | ENST00000673416.1 [Q7Z2E3-4] ENST00000483148.6 ENST00000673598.1 [Q7Z2E3-2] ENST00000495360.6 ENST00000472896.6 ENST00000379817.7 [Q7Z2E3-7] ENST00000480031.6 ENST00000467331.6 [Q7Z2E3-12] Q7Z2E3 ENST00000477119.2 F8WBD6 ENST00000479656.6 [Q7Z2E3-12] A0A5K1VW64 ENST00000474658.7 C9J8U3 ENST00000673487.1 [Q7Z2E3-12] ENST00000397172.8 Q6JV79 A0A0A0MRW7 ENST00000309615.8 [Q7Z2E3-5] ENST00000476858.6 [Q7Z2E3-5] A0A5F9ZGW5 ENST00000671912.1 ENST00000673248.1 [Q7Z2E3-4] A0A5K1VW80 F8WBM3 ENST00000485479.6 [Q7Z2E3-12] F5HRF8 A0A5F9ZI51 ENST00000482687.6 [Q7Z2E3-12] ENST00000468275.6 [Q7Z2E3-9] ENST00000673360.1 ENST00000494649.5 [Q7Z2E3-12] ENST00000379825.7 [Q7Z2E3-9] ENST00000672244.1 ENST00000672519.1 [Q7Z2E3-12] ENST00000672438.1 [Q7Z2E3-4] ENST00000478279.6 ENST00000379819.6 [Q7Z2E3-7] ENST00000465003.6 [Q7Z2E3-12] ENST00000672535.1 [Q7Z2E3-12] ENST00000463596.6 [Q7Z2E3-7] ENST00000379813.7 ENST00000460940.6 [Q7Z2E3-12] ENST00000672846.1 [Q7Z2E3-12] ENST00000436040.7 [Q7Z2E3-5] ENST00000464632.6 [Q7Z2E3-12] |