APTX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000012Biological processsingle strand break repair
GO_0006266Biological processDNA ligation
GO_0031647Biological processregulation of protein stability
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_1990165Molecular functionsingle-strand break-containing DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0030983Molecular functionmismatched DNA binding
GO_0008967Molecular functionphosphoglycolate phosphatase activity
GO_0120108Molecular functionDNA-3'-diphospho-5'-guanosine diphosphatase
GO_0046872Molecular functionmetal ion binding
GO_0033699Molecular functionDNA 5'-adenosine monophosphate hydrolase activity
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameAPTX
Protein nameAprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)
Aprataxin
Aprataxin (Aprataxin variant LP3E5)
Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein)
SynonymsAXA1
DescriptionFUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair . Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species . Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined . Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity . Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). .

AccessionsENST00000673416.1 [Q7Z2E3-4]
ENST00000483148.6
ENST00000673598.1 [Q7Z2E3-2]
ENST00000495360.6
ENST00000472896.6
ENST00000379817.7 [Q7Z2E3-7]
ENST00000480031.6
ENST00000467331.6 [Q7Z2E3-12]
Q7Z2E3
ENST00000477119.2
F8WBD6
ENST00000479656.6 [Q7Z2E3-12]
A0A5K1VW64
ENST00000474658.7
C9J8U3
ENST00000673487.1 [Q7Z2E3-12]
ENST00000397172.8
Q6JV79
A0A0A0MRW7
ENST00000309615.8 [Q7Z2E3-5]
ENST00000476858.6 [Q7Z2E3-5]
A0A5F9ZGW5
ENST00000671912.1
ENST00000673248.1 [Q7Z2E3-4]
A0A5K1VW80
F8WBM3
ENST00000485479.6 [Q7Z2E3-12]
F5HRF8
A0A5F9ZI51
ENST00000482687.6 [Q7Z2E3-12]
ENST00000468275.6 [Q7Z2E3-9]
ENST00000673360.1
ENST00000494649.5 [Q7Z2E3-12]
ENST00000379825.7 [Q7Z2E3-9]
ENST00000672244.1
ENST00000672519.1 [Q7Z2E3-12]
ENST00000672438.1 [Q7Z2E3-4]
ENST00000478279.6
ENST00000379819.6 [Q7Z2E3-7]
ENST00000465003.6 [Q7Z2E3-12]
ENST00000672535.1 [Q7Z2E3-12]
ENST00000463596.6 [Q7Z2E3-7]
ENST00000379813.7
ENST00000460940.6 [Q7Z2E3-12]
ENST00000672846.1 [Q7Z2E3-12]
ENST00000436040.7 [Q7Z2E3-5]
ENST00000464632.6 [Q7Z2E3-12]