APOBEC3D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of APOBEC3D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APOBEC3D at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0016554Biological processcytidine to uridine editing
GO_0044355Biological processclearance of foreign intracellular DNA
GO_0070383Biological processDNA cytosine deamination
GO_0009972Biological processcytidine deamination
GO_0045087Biological processinnate immune response
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008270Molecular functionzinc ion binding
GO_0004126Molecular functioncytidine deaminase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAPOBEC3D
Protein nameDNA dC->dU-editing enzyme APOBEC-3D (A3D) (A3DE) (EC 3.5.4.38)
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D (BK150C2.9 protein) (HCG41704, isoform CRA_b)
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D
SynonymsbK150C2.9
hCG_41704
APOBEC3DE
DescriptionFUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms . Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA . The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons . .; FUNCTION: (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids. .

AccessionsQ96AK3
ENST00000427494.6
A0A087WX48
Q6ICH2
ENST00000622217.3
ENST00000216099.13