I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 47% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 47% ± 22% |
Insufficient scRNA-seq data for expression of APOA5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 22510.73 | 226 / 226 | 92% | 278.98 | 374 / 406 |
| pancreas | 88% | 107.48 | 289 / 328 | 2% | 0.04 | 3 / 178 |
| lung | 51% | 5.83 | 297 / 578 | 2% | 0.16 | 28 / 1155 |
| thymus | 47% | 3.31 | 310 / 653 | 1% | 0.03 | 8 / 605 |
| stomach | 40% | 2.84 | 144 / 359 | 7% | 0.23 | 20 / 286 |
| prostate | 37% | 2.96 | 91 / 245 | 0% | 0.01 | 2 / 502 |
| intestine | 35% | 5.55 | 335 / 966 | 2% | 0.43 | 13 / 527 |
| blood vessel | 35% | 2.65 | 463 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 34% | 2.50 | 58 / 170 | 0% | 0.01 | 2 / 459 |
| bladder | 29% | 1.29 | 6 / 21 | 1% | 0.05 | 3 / 504 |
| breast | 26% | 3.25 | 120 / 459 | 2% | 0.07 | 20 / 1118 |
| spleen | 28% | 33.03 | 67 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 25% | 1.74 | 365 / 1445 | 2% | 0.05 | 4 / 183 |
| peripheral blood | 23% | 6.69 | 216 / 929 | 0% | 0 | 0 / 0 |
| skin | 22% | 1.91 | 400 / 1809 | 1% | 0.02 | 5 / 472 |
| adipose | 23% | 5.78 | 278 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 23% | 1.72 | 59 / 258 | 0% | 0 | 0 / 230 |
| brain | 20% | 1.14 | 540 / 2642 | 0% | 0.00 | 1 / 705 |
| ovary | 19% | 1.08 | 34 / 180 | 0% | 0.01 | 2 / 430 |
| kidney | 17% | 0.79 | 15 / 89 | 1% | 0.45 | 6 / 901 |
| muscle | 12% | 0.71 | 94 / 803 | 0% | 0 | 0 / 0 |
| heart | 11% | 0.69 | 98 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070328 | Biological process | triglyceride homeostasis |
| GO_0010898 | Biological process | positive regulation of triglyceride catabolic process |
| GO_0045723 | Biological process | positive regulation of fatty acid biosynthetic process |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0042246 | Biological process | tissue regeneration |
| GO_0033700 | Biological process | phospholipid efflux |
| GO_0042157 | Biological process | lipoprotein metabolic process |
| GO_0055090 | Biological process | acylglycerol homeostasis |
| GO_0050996 | Biological process | positive regulation of lipid catabolic process |
| GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
| GO_0019433 | Biological process | triglyceride catabolic process |
| GO_0034370 | Biological process | triglyceride-rich lipoprotein particle remodeling |
| GO_0006641 | Biological process | triglyceride metabolic process |
| GO_0010902 | Biological process | positive regulation of very-low-density lipoprotein particle remodeling |
| GO_0051006 | Biological process | positive regulation of lipoprotein lipase activity |
| GO_0033344 | Biological process | cholesterol efflux |
| GO_0006869 | Biological process | lipid transport |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0042627 | Cellular component | chylomicron |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005769 | Cellular component | early endosome |
| GO_0034362 | Cellular component | low-density lipoprotein particle |
| GO_1903561 | Cellular component | extracellular vesicle |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0034364 | Cellular component | high-density lipoprotein particle |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0034361 | Cellular component | very-low-density lipoprotein particle |
| GO_0005770 | Cellular component | late endosome |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0008201 | Molecular function | heparin binding |
| GO_0008289 | Molecular function | lipid binding |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0060228 | Molecular function | phosphatidylcholine-sterol O-acyltransferase activator activity |
| GO_0120020 | Molecular function | cholesterol transfer activity |
| GO_0060230 | Molecular function | lipoprotein lipase activator activity |
| GO_0050750 | Molecular function | low-density lipoprotein particle receptor binding |
| GO_0031210 | Molecular function | phosphatidylcholine binding |
| GO_0060229 | Molecular function | lipase activator activity |
| GO_0070325 | Molecular function | lipoprotein particle receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0035473 | Molecular function | lipase binding |
| Gene name | APOA5 |
| Protein name | Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3) Apolipoprotein A-V (Apolipoprotein A5) |
| Synonyms | UNQ411/PRO773 RAP3 hCG_1642845 |
| Description | FUNCTION: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin . . |
| Accessions | Q6Q788 A0A0B4RUS7 ENST00000673688.1 A0A669KB69 ENST00000542499.5 B0YIW1 ENST00000227665.9 ENST00000433069.2 |
