AP4M1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AP4M1 at tissue level.

III. Associated gene sets

GO_0006622Biological processprotein targeting to lysosome
GO_0000045Biological processautophagosome assembly
GO_1903361Biological processprotein localization to basolateral plasma membrane
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0006886Biological processintracellular protein transport
GO_0006605Biological processprotein targeting
GO_0016192Biological processvesicle-mediated transport
GO_0090160Biological processGolgi to lysosome transport
GO_0008104Biological processprotein localization
GO_0071806Biological processprotein transmembrane transport
GO_0006895Biological processGolgi to endosome transport
GO_0030124Cellular componentAP-4 adaptor complex
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0030131Cellular componentclathrin adaptor complex
GO_0005829Cellular componentcytosol
GO_0031904Cellular componentendosome lumen
GO_0019904Molecular functionprotein domain specific binding
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP4M1
Protein nameAdaptor related protein complex 4 subunit mu 1
AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)
AP-4 complex subunit mu-1
SynonymsMUARP2
DescriptionFUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system . It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos . The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). .

FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal. .

FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal. .

AccessionsH7C0A0
F8WCR6
ENST00000445295.1
ENST00000421755.5
ENST00000438383.5
F8WCC5
ENST00000446007.5
ENST00000445208.5
H0Y6K1
ENST00000422582.5
H7BZV3
C9JWL4
ENST00000359593.9
ENST00000450807.5
C9JMG3
C9IZL5
ENST00000429084.5
F8WDR3
ENST00000416938.5
ENST00000394061.7
ENST00000439416.5
O00189
C9JC87