AP3M1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046907Biological processintracellular transport
GO_0006897Biological processendocytosis
GO_0006622Biological processprotein targeting to lysosome
GO_0035654Biological processclathrin-coated vesicle cargo loading, AP-3-mediated
GO_0008089Biological processanterograde axonal transport
GO_0048490Biological processanterograde synaptic vesicle transport
GO_0016192Biological processvesicle-mediated transport
GO_0060155Biological processplatelet dense granule organization
GO_1903232Biological processmelanosome assembly
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0005794Cellular componentGolgi apparatus
GO_0030123Cellular componentAP-3 adaptor complex
GO_0030131Cellular componentclathrin adaptor complex
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_1904115Cellular componentaxon cytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP3M1
Protein nameAP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)
Synonyms
DescriptionFUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

AccessionsENST00000355264.9
ENST00000372745.1
Q9Y2T2