ANAPC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007091Biological processmetaphase/anaphase transition of mitotic cell cycle
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0051301Biological processcell division
GO_0051445Biological processregulation of meiotic cell cycle
GO_0007346Biological processregulation of mitotic cell cycle
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameANAPC1
Protein nameAnaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)
Anaphase promoting complex subunit 1
SynonymsTSG24
DescriptionFUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .

AccessionsENST00000341068.8
ENST00000643447.1
ENST00000628342.1
ENST00000427997.5
F8WAS1
Q9H1A4
A0A2R8YF63
H0Y564
ENST00000451367.3