ALDOB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0006096Biological processglycolytic process
GO_0006000Biological processfructose metabolic process
GO_0006116Biological processNADH oxidation
GO_0061624Biological processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
GO_0030388Biological processfructose 1,6-bisphosphate metabolic process
GO_0006094Biological processgluconeogenesis
GO_0070072Biological processvacuolar proton-transporting V-type ATPase complex assembly
GO_1905856Biological processnegative regulation of pentose-phosphate shunt
GO_0034451Cellular componentcentriolar satellite
GO_0005815Cellular componentmicrotubule organizing center
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0004332Molecular functionfructose-bisphosphate aldolase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0061609Molecular functionfructose-1-phosphate aldolase activity
GO_0051117Molecular functionATPase binding
GO_0070061Molecular functionfructose binding
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALDOB
Protein nameFructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase)
Fructose-bisphosphate aldolase (EC 4.1.2.13)
SynonymsALDB
DescriptionFUNCTION: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde . Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check . .

AccessionsENST00000648758.1
ENST00000649902.1
A0A3B3ITZ0
P05062
ENST00000647789.2
ENST00000648064.1
A0A3B3IS80
ENST00000648423.1