Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 4 studies | 34% ± 16% | |
goblet cell | 4 studies | 29% ± 18% | |
endothelial cell | 3 studies | 21% ± 3% | |
GABAergic neuron | 3 studies | 28% ± 9% | |
glutamatergic neuron | 3 studies | 35% ± 9% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 5% | |
enterocyte | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2115.24 | 459 / 459 | 100% | 139.60 | 1118 / 1118 |
intestine | 100% | 4462.57 | 966 / 966 | 100% | 139.89 | 527 / 527 |
ovary | 100% | 2270.73 | 180 / 180 | 100% | 88.33 | 430 / 430 |
pancreas | 100% | 4224.46 | 328 / 328 | 100% | 84.44 | 178 / 178 |
stomach | 100% | 3319.66 | 359 / 359 | 100% | 131.89 | 286 / 286 |
esophagus | 100% | 2135.67 | 1444 / 1445 | 100% | 92.42 | 183 / 183 |
bladder | 100% | 2306.71 | 21 / 21 | 100% | 97.46 | 503 / 504 |
prostate | 100% | 2778.62 | 245 / 245 | 100% | 114.73 | 501 / 502 |
skin | 100% | 4309.13 | 1807 / 1809 | 100% | 97.67 | 471 / 472 |
thymus | 100% | 4493.50 | 653 / 653 | 100% | 90.28 | 603 / 605 |
uterus | 100% | 2161.46 | 170 / 170 | 99% | 89.25 | 456 / 459 |
lung | 99% | 1868.71 | 573 / 578 | 100% | 97.55 | 1155 / 1155 |
brain | 99% | 1523.59 | 2605 / 2642 | 100% | 57.81 | 705 / 705 |
kidney | 100% | 2325.24 | 89 / 89 | 97% | 69.55 | 877 / 901 |
adrenal gland | 100% | 2573.66 | 258 / 258 | 94% | 50.10 | 217 / 230 |
liver | 99% | 2123.29 | 223 / 226 | 92% | 46.93 | 374 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 83.61 | 29 / 29 |
spleen | 100% | 1998.10 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 62.31 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 56.66 | 1 / 1 |
adipose | 100% | 1775.07 | 1202 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2702.72 | 1331 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 48.99 | 79 / 80 |
heart | 87% | 1059.83 | 749 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 44% | 2159.51 | 408 / 929 | 0% | 0 | 0 / 0 |
muscle | 30% | 216.33 | 238 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006536 | Biological process | glutamate metabolic process |
GO_0019240 | Biological process | citrulline biosynthetic process |
GO_0006592 | Biological process | ornithine biosynthetic process |
GO_0055129 | Biological process | L-proline biosynthetic process |
GO_0009266 | Biological process | response to temperature stimulus |
GO_0006561 | Biological process | proline biosynthetic process |
GO_0005739 | Cellular component | mitochondrion |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0004350 | Molecular function | glutamate-5-semialdehyde dehydrogenase activity |
GO_0004349 | Molecular function | glutamate 5-kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | ALDH18A1 |
Protein name | Aldehyde dehydrogenase 18 family member A1 Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] |
Synonyms | P5CS GSAS PYCS |
Description | FUNCTION: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. . |
Accessions | A0A2Z4QJG5 A0A2Z4QJH0 P54886 ENST00000371221.3 [P54886-2] A0A2Z4QJC8 ENST00000371224.7 [P54886-1] |