ALDH18A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006536Biological processglutamate metabolic process
GO_0019240Biological processcitrulline biosynthetic process
GO_0006592Biological processornithine biosynthetic process
GO_0055129Biological processL-proline biosynthetic process
GO_0009266Biological processresponse to temperature stimulus
GO_0006561Biological processproline biosynthetic process
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0004350Molecular functionglutamate-5-semialdehyde dehydrogenase activity
GO_0004349Molecular functionglutamate 5-kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameALDH18A1
Protein nameAldehyde dehydrogenase 18 family member A1
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]
SynonymsP5CS
GSAS
PYCS
DescriptionFUNCTION: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. .

AccessionsA0A2Z4QJG5
A0A2Z4QJH0
P54886
ENST00000371221.3 [P54886-2]
A0A2Z4QJC8
ENST00000371224.7 [P54886-1]