Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 8 studies | 27% ± 7% | |
| epithelial cell | 4 studies | 26% ± 6% | |
| endothelial cell | 4 studies | 18% ± 2% | |
| ciliated cell | 4 studies | 20% ± 3% | |
| hepatocyte | 3 studies | 40% ± 18% | |
| macrophage | 3 studies | 22% ± 8% | |
| abnormal cell | 3 studies | 16% ± 1% |
Insufficient scRNA-seq data for expression of ALAS1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 9070.38 | 226 / 226 | 100% | 268.45 | 406 / 406 |
| intestine | 100% | 3078.06 | 965 / 966 | 100% | 100.47 | 527 / 527 |
| esophagus | 100% | 2448.79 | 1442 / 1445 | 100% | 73.71 | 183 / 183 |
| stomach | 100% | 2989.21 | 358 / 359 | 100% | 96.91 | 286 / 286 |
| skin | 100% | 2272.78 | 1807 / 1809 | 100% | 108.54 | 471 / 472 |
| lung | 100% | 3672.58 | 576 / 578 | 100% | 84.54 | 1155 / 1155 |
| breast | 100% | 2720.92 | 459 / 459 | 99% | 70.98 | 1112 / 1118 |
| bladder | 100% | 3184.29 | 21 / 21 | 99% | 142.18 | 500 / 504 |
| thymus | 100% | 2223.95 | 651 / 653 | 99% | 66.59 | 601 / 605 |
| prostate | 100% | 2166.33 | 244 / 245 | 99% | 71.22 | 499 / 502 |
| uterus | 100% | 1696.07 | 170 / 170 | 99% | 79.84 | 454 / 459 |
| ovary | 98% | 1585.34 | 177 / 180 | 100% | 69.89 | 430 / 430 |
| kidney | 100% | 3458.70 | 89 / 89 | 97% | 62.97 | 878 / 901 |
| brain | 96% | 2408.93 | 2527 / 2642 | 100% | 67.59 | 704 / 705 |
| adrenal gland | 100% | 58844.64 | 258 / 258 | 95% | 191.58 | 219 / 230 |
| pancreas | 83% | 830.21 | 272 / 328 | 99% | 89.47 | 176 / 178 |
| adipose | 100% | 3033.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 141.64 | 29 / 29 |
| muscle | 100% | 4829.73 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1709.36 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 74.45 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 66.43 | 1 / 1 |
| blood vessel | 99% | 1716.46 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 46.29 | 79 / 80 |
| peripheral blood | 99% | 3792.78 | 916 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 5298.59 | 839 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1903412 | Biological process | response to bile acid |
| GO_0006782 | Biological process | protoporphyrinogen IX biosynthetic process |
| GO_0048821 | Biological process | erythrocyte development |
| GO_0006783 | Biological process | heme biosynthetic process |
| GO_0006784 | Biological process | heme A biosynthetic process |
| GO_0048034 | Biological process | heme O biosynthetic process |
| GO_0042541 | Biological process | hemoglobin biosynthetic process |
| GO_0006785 | Biological process | heme B biosynthetic process |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| GO_0003870 | Molecular function | 5-aminolevulinate synthase activity |
| Gene name | ALAS1 |
| Protein name | 5'-aminolevulinate synthase 1 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-ALA synthase) (Delta-aminolevulinate synthase) 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) |
| Synonyms | OK/SW-cl.121 hCG_42575 ALASH ALAS3 |
| Description | FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. . FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. . |
| Accessions | ENST00000310271.6 [P13196-1] ENST00000493402.1 P13196 H7C5B0 ENST00000459884.1 ENST00000394965.6 [P13196-1] Q5JAM2 ENST00000484952.6 [P13196-1] H7C4H7 ENST00000469224.5 [P13196-1] |
