AKR1C1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044597Biological processdaunorubicin metabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0008206Biological processbile acid metabolic process
GO_0030299Biological processintestinal cholesterol absorption
GO_0071395Biological processcellular response to jasmonic acid stimulus
GO_0044598Biological processdoxorubicin metabolic process
GO_0030855Biological processepithelial cell differentiation
GO_0007586Biological processdigestion
GO_0042448Biological processprogesterone metabolic process
GO_0015721Biological processbile acid and bile salt transport
GO_0001523Biological processretinoid metabolic process
GO_0042574Biological processretinal metabolic process
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0042632Biological processcholesterol homeostasis
GO_0046683Biological processresponse to organophosphorus
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0047024Molecular function5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO_0047086Molecular functionketosteroid monooxygenase activity
GO_0018636Molecular functionphenanthrene 9,10-monooxygenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0016655Molecular functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO_0047006Molecular function17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO_0047023Molecular functionandrosterone dehydrogenase activity
GO_0047044Molecular functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
GO_0047718Molecular functionindanol dehydrogenase activity
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0033703Molecular function3beta-hydroxy-5beta-steroid dehydrogenase activity
GO_0032052Molecular functionbile acid binding
GO_0047042Molecular functionandrosterone dehydrogenase (B-specific) activity
GO_0047045Molecular functiontestosterone 17-beta-dehydrogenase (NADP+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0030283Molecular functiontestosterone dehydrogenase [NAD(P)+] activity
GO_0031406Molecular functioncarboxylic acid binding
GO_0033764Molecular functionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO_0035410Molecular functiondihydrotestosterone 17-beta-dehydrogenase activity
GO_0005515Molecular functionprotein binding
GO_0047115Molecular functiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

IV. Literature review

[source]
Gene nameAKR1C1
Protein nameAldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB)
Aldo-keto reductase family 1 member C1
SynonymsDDH1
DDH
DescriptionFUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids . Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH . Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens . May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate . Displays affinity for bile acids . .

AccessionsENST00000380859.1
A6NHU4
H0Y804
Q04828
ENST00000442997.5
ENST00000380872.9