AIFM2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AIFM2 at tissue level.

III. Associated gene sets

GO_0110076Biological processnegative regulation of ferroptosis
GO_1990748Biological processcellular detoxification
GO_0042373Biological processvitamin K metabolic process
GO_0008637Biological processapoptotic mitochondrial changes
GO_0022904Biological processrespiratory electron transport chain
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0006743Biological processubiquinone metabolic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0016655Molecular functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO_0004174Molecular functionelectron-transferring-flavoprotein dehydrogenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAIFM2
Protein nameFerroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
SynonymsAMID
PRG3
DescriptionFUNCTION: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis . At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis . Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis . This anti-ferroptotic function is independent of cellular glutathione levels . Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms . Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis . May play a role in mitochondrial stress signaling . Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death . Capable of DNA binding in a non-sequence specific way . .

AccessionsENST00000307864.3 [Q9BRQ8-1]
ENST00000613322.4 [Q9BRQ8-1]
Q9BRQ8
ENST00000373248.5 [Q9BRQ8-1]