AFG3L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034982Biological processmitochondrial protein processing
GO_0042552Biological processmyelination
GO_0021675Biological processnerve development
GO_0033619Biological processmembrane protein proteolysis
GO_0055001Biological processmuscle cell development
GO_0016540Biological processprotein autoprocessing
GO_0016485Biological processprotein processing
GO_0008053Biological processmitochondrial fusion
GO_0040014Biological processregulation of multicellular organism growth
GO_0060013Biological processrighting reflex
GO_0141164Biological processmitochondrial protein quality control
GO_0007528Biological processneuromuscular junction development
GO_0072753Biological processcellular response to glutathione
GO_0007409Biological processaxonogenesis
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0042407Biological processcristae formation
GO_0006508Biological processproteolysis
GO_0030163Biological processprotein catabolic process
GO_0110097Biological processregulation of calcium import into the mitochondrion
GO_0036444Biological processcalcium import into the mitochondrion
GO_0051604Biological processprotein maturation
GO_0005739Cellular componentmitochondrion
GO_0005745Cellular componentm-AAA complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0004176Molecular functionATP-dependent peptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0051082Molecular functionunfolded protein binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameAFG3L2
Protein nameAFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)
AFG3 like matrix AAA peptidase subunit 2
Synonyms
DescriptionFUNCTION: ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU . Required for paraplegin (SPG7) maturation . After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) . Involved in the regulation of OMA1-dependent processing of OPA1 . Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria . Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 . .

AccessionsA0A8I5QJR7
A0A8I5KXN0
A0A8I5KVV1
Q9Y4W6
K7EP56
ENST00000692497.1
A0A8I5KRT8
ENST00000691970.1
ENST00000590811.1
ENST00000691179.1
ENST00000688199.1
A0A8I5KYF5
ENST00000269143.8
ENST00000687337.1