Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 8 studies | 23% ± 5% | |
epithelial cell | 8 studies | 32% ± 13% | |
adipocyte | 6 studies | 20% ± 4% | |
basal cell | 5 studies | 28% ± 10% | |
cardiac muscle cell | 5 studies | 32% ± 9% | |
goblet cell | 5 studies | 24% ± 8% | |
oligodendrocyte | 5 studies | 20% ± 3% | |
fibroblast | 4 studies | 18% ± 2% | |
astrocyte | 4 studies | 29% ± 7% | |
macrophage | 4 studies | 19% ± 4% | |
ionocyte | 3 studies | 25% ± 7% | |
secretory cell | 3 studies | 24% ± 10% | |
ciliated cell | 3 studies | 32% ± 6% | |
GABAergic neuron | 3 studies | 43% ± 11% | |
glutamatergic neuron | 3 studies | 49% ± 16% | |
oligodendrocyte precursor cell | 3 studies | 27% ± 7% | |
dendritic cell | 3 studies | 28% ± 9% | |
abnormal cell | 3 studies | 21% ± 3% | |
transit amplifying cell | 3 studies | 31% ± 14% | |
interneuron | 3 studies | 34% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 2267.50 | 358 / 359 | 100% | 22.68 | 286 / 286 |
intestine | 100% | 2887.12 | 966 / 966 | 99% | 25.35 | 524 / 527 |
esophagus | 100% | 2258.11 | 1442 / 1445 | 99% | 23.85 | 182 / 183 |
ovary | 100% | 1940.88 | 180 / 180 | 99% | 21.90 | 425 / 430 |
breast | 100% | 2172.95 | 459 / 459 | 99% | 27.19 | 1102 / 1118 |
skin | 100% | 3083.33 | 1809 / 1809 | 98% | 39.31 | 464 / 472 |
lung | 99% | 1715.73 | 570 / 578 | 99% | 23.05 | 1143 / 1155 |
bladder | 100% | 2146.24 | 21 / 21 | 97% | 22.97 | 491 / 504 |
prostate | 100% | 1664.24 | 245 / 245 | 97% | 22.62 | 489 / 502 |
pancreas | 99% | 1528.89 | 326 / 328 | 98% | 20.18 | 174 / 178 |
kidney | 100% | 2764.99 | 89 / 89 | 97% | 30.56 | 874 / 901 |
uterus | 100% | 1773.92 | 170 / 170 | 95% | 22.36 | 438 / 459 |
thymus | 100% | 2619.33 | 653 / 653 | 95% | 20.97 | 577 / 605 |
brain | 96% | 1658.28 | 2531 / 2642 | 98% | 19.08 | 692 / 705 |
liver | 100% | 1689.52 | 225 / 226 | 91% | 15.73 | 368 / 406 |
adrenal gland | 100% | 2499.96 | 258 / 258 | 86% | 15.75 | 198 / 230 |
adipose | 100% | 2199.45 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 6956.74 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1510.78 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.26 | 1 / 1 |
blood vessel | 100% | 1553.04 | 1332 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 45.37 | 79 / 80 |
lymph node | 0% | 0 | 0 / 0 | 97% | 21.88 | 28 / 29 |
tonsil | 0% | 0 | 0 / 0 | 96% | 26.04 | 43 / 45 |
heart | 95% | 3922.64 | 816 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 53% | 1270.65 | 488 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0034982 | Biological process | mitochondrial protein processing |
GO_0042552 | Biological process | myelination |
GO_0021675 | Biological process | nerve development |
GO_0033619 | Biological process | membrane protein proteolysis |
GO_0055001 | Biological process | muscle cell development |
GO_0016540 | Biological process | protein autoprocessing |
GO_0016485 | Biological process | protein processing |
GO_0008053 | Biological process | mitochondrial fusion |
GO_0040014 | Biological process | regulation of multicellular organism growth |
GO_0060013 | Biological process | righting reflex |
GO_0141164 | Biological process | mitochondrial protein quality control |
GO_0007528 | Biological process | neuromuscular junction development |
GO_0072753 | Biological process | cellular response to glutathione |
GO_0007409 | Biological process | axonogenesis |
GO_0051560 | Biological process | mitochondrial calcium ion homeostasis |
GO_0042407 | Biological process | cristae formation |
GO_0006508 | Biological process | proteolysis |
GO_0030163 | Biological process | protein catabolic process |
GO_0110097 | Biological process | regulation of calcium import into the mitochondrion |
GO_0036444 | Biological process | calcium import into the mitochondrion |
GO_0051604 | Biological process | protein maturation |
GO_0005739 | Cellular component | mitochondrion |
GO_0005745 | Cellular component | m-AAA complex |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0004176 | Molecular function | ATP-dependent peptidase activity |
GO_0008237 | Molecular function | metallopeptidase activity |
GO_0051082 | Molecular function | unfolded protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004222 | Molecular function | metalloendopeptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | AFG3L2 |
Protein name | AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) AFG3 like matrix AAA peptidase subunit 2 |
Synonyms | |
Description | FUNCTION: ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU . Required for paraplegin (SPG7) maturation . After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) . Involved in the regulation of OMA1-dependent processing of OPA1 . Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria . Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 . . |
Accessions | A0A8I5QJR7 A0A8I5KXN0 A0A8I5KVV1 Q9Y4W6 K7EP56 ENST00000692497.1 A0A8I5KRT8 ENST00000691970.1 ENST00000590811.1 ENST00000691179.1 ENST00000688199.1 A0A8I5KYF5 ENST00000269143.8 ENST00000687337.1 |