ADCY7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADCY7 at tissue level.

III. Associated gene sets

GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0035556Biological processintracellular signal transduction
GO_0006171Biological processcAMP biosynthetic process
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0071361Biological processcellular response to ethanol
GO_0002819Biological processregulation of adaptive immune response
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0071285Biological processcellular response to lithium ion
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0004016Molecular functionadenylate cyclase activity
GO_0005524Molecular functionATP binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameADCY7
Protein nameadenylate cyclase (EC 4.6.1.1)
Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)
Adenylate cyclase 7
SynonymsKIAA0037
DescriptionFUNCTION: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 . Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex . Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). .

AccessionsENST00000564965.5
H3BMA5
ENST00000254235.7
ENST00000394697.7
ENST00000566433.6
H3BQ93
F5H699
ENST00000566761.2
F5H4D1
ENST00000537579.5
P51828
I3L2Y1
ENST00000567277.6
ENST00000673973.1
I3L3Q5
ENST00000569265.1
A0A669KBF7
ENST00000564044.5
ENST00000673801.1