ADCY6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_0006171Biological processcAMP biosynthetic process
GO_0003091Biological processrenal water homeostasis
GO_0097746Biological processblood vessel diameter maintenance
GO_1904117Biological processcellular response to vasopressin
GO_0035811Biological processnegative regulation of urine volume
GO_0071870Biological processcellular response to catecholamine stimulus
GO_0035556Biological processintracellular signal transduction
GO_0010977Biological processnegative regulation of neuron projection development
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_1904322Biological processcellular response to forskolin
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_0032420Cellular componentstereocilium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005929Cellular componentcilium
GO_0005080Molecular functionprotein kinase C binding
GO_0004016Molecular functionadenylate cyclase activity
GO_0019901Molecular functionprotein kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameADCY6
Protein nameAdenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase)
Adenylate cyclase 6
SynonymsKIAA0422
DescriptionFUNCTION: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors . Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells . Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol . Contributes to bone cell responses to mechanical stimuli (By similarity). .

AccessionsENST00000357869.8 [O43306-1]
ENST00000548820.1
O43306
F8VZJ5
ENST00000307885.4 [O43306-1]
ENST00000550422.5 [O43306-2]