ADAMTS12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030167Biological processproteoglycan catabolic process
GO_1901509Biological processregulation of endothelial tube morphogenesis
GO_0071773Biological processcellular response to BMP stimulus
GO_1902548Biological processnegative regulation of cellular response to vascular endothelial growth factor stimulus
GO_0007160Biological processcell-matrix adhesion
GO_0002062Biological processchondrocyte differentiation
GO_1902203Biological processnegative regulation of hepatocyte growth factor receptor signaling pathway
GO_0030198Biological processextracellular matrix organization
GO_0071347Biological processcellular response to interleukin-1
GO_0050727Biological processregulation of inflammatory response
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0006508Biological processproteolysis
GO_2001113Biological processnegative regulation of cellular response to hepatocyte growth factor stimulus
GO_0030199Biological processcollagen fibril organization
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0043931Biological processossification involved in bone maturation
GO_0016477Biological processcell migration
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0046872Molecular functionmetal ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameADAMTS12
Protein nameADAM metallopeptidase with thrombospondin type 1 motif 12
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)
A disintegrin and metalloproteinase with thrombospondin motifs 12
SynonymsUNQ1918/PRO4389
DescriptionFUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. .

AccessionsENST00000504830.6 [P58397-1]
ENST00000515401.1
P58397
A0A0G2JRM9
ENST00000630537.2
D6REX0
ENST00000352040.7 [P58397-3]
ENST00000630002.1