ACSS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019413Biological processacetate biosynthetic process
GO_0006085Biological processacetyl-CoA biosynthetic process
GO_0019542Biological processpropionate biosynthetic process
GO_0019427Biological processacetyl-CoA biosynthetic process from acetate
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0003987Molecular functionacetate-CoA ligase activity
GO_0016208Molecular functionAMP binding
GO_0050218Molecular functionpropionate-CoA ligase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACSS1
Protein nameAcyl-CoA synthetase short chain family member 1
Acetyl-coenzyme A synthetase (EC 6.2.1.1)
acetate--CoA ligase (EC 6.2.1.1)
Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)
SynonymsACAS2L
KIAA1846
DescriptionFUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids . Acetate is the preferred substrate . Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). .

AccessionsENST00000323482.9 [Q9NUB1-1]
ENST00000432802.6 [Q9NUB1-4]
ENST00000376726.3
Q7Z5G3
Q1RMZ4
Q9NUB1
ENST00000537502.5 [Q9NUB1-3]
Q5TF43