ACSM1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACSM1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	321.70	245 / 245	99%	126.71	499 / 502
liver	95%	175.89	215 / 226	84%	39.17	340 / 406
pancreas	100%	91.37	327 / 328	75%	2.22	133 / 178
thymus	95%	43.06	622 / 653	75%	2.01	455 / 605
kidney	99%	90.40	88 / 89	65%	4.44	585 / 901
breast	75%	138.97	345 / 459	72%	11.92	804 / 1118
stomach	100%	147.52	359 / 359	30%	0.53	85 / 286
bladder	95%	97.57	20 / 21	32%	0.79	163 / 504
ovary	100%	305.08	180 / 180	26%	0.51	113 / 430
intestine	96%	78.05	924 / 966	28%	0.59	150 / 527
lung	92%	50.99	531 / 578	30%	0.67	352 / 1155
uterus	100%	220.59	170 / 170	16%	0.34	74 / 459
esophagus	90%	53.01	1294 / 1445	13%	0.25	23 / 183
spleen	96%	37.48	232 / 241	0%	0	0 / 0
adrenal gland	78%	41.56	201 / 258	17%	1.67	40 / 230
blood vessel	93%	66.64	1241 / 1335	0%	0	0 / 0
heart	76%	29.66	651 / 861	0%	0	0 / 0
skin	71%	80.73	1284 / 1809	1%	0.02	7 / 472
adipose	62%	26.80	747 / 1204	0%	0	0 / 0
brain	54%	17.83	1428 / 2642	0%	0.00	2 / 705
peripheral blood	36%	9.90	333 / 929	0%	0	0 / 0
muscle	31%	8.01	249 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	9%	0.11	4 / 45
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006805	Biological process	xenobiotic metabolic process
GO_0015980	Biological process	energy derivation by oxidation of organic compounds
GO_0019395	Biological process	fatty acid oxidation
GO_0018874	Biological process	benzoate metabolic process
GO_0042632	Biological process	cholesterol homeostasis
GO_0006633	Biological process	fatty acid biosynthetic process
GO_0001676	Biological process	long-chain fatty acid metabolic process
GO_0006637	Biological process	acyl-CoA metabolic process
GO_0019605	Biological process	butyrate metabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0072562	Cellular component	blood microparticle
GO_0005759	Cellular component	mitochondrial matrix
GO_0102391	Molecular function	decanoate-CoA ligase activity
GO_0031956	Molecular function	medium-chain fatty acid-CoA ligase activity
GO_0004321	Molecular function	fatty-acyl-CoA synthase activity
GO_0004467	Molecular function	long-chain fatty acid-CoA ligase activity
GO_0015645	Molecular function	fatty acid ligase activity
GO_0005525	Molecular function	GTP binding
GO_0016405	Molecular function	CoA-ligase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0018858	Molecular function	benzoate-CoA ligase activity

Gene name	ACSM1
Protein name	Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B) medium-chain acyl-CoA ligase (EC 6.2.1.2) Acyl-CoA synthetase medium-chain family member 1, isoform CRA_b (Gene with similarity to rat kidney-specific (KS) gene)
Synonyms	LAE MACS1 hCG_1818814 A-923A4.2 BUCS1
Description	FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism . Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate . Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). .
Accessions	E5RFK0 ENST00000520010.6 [Q08AH1-1] O75203 Q08AH1 ENST00000524149.5 H0YAU5 ENST00000523065.1 ENST00000307493.8 [Q08AH1-1] ENST00000519745.5 [Q08AH1-2]

ACSM1 report