ACP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACP3 at tissue level.

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0006144Biological processpurine nucleobase metabolic process
GO_0009117Biological processnucleotide metabolic process
GO_0051930Biological processregulation of sensory perception of pain
GO_0046085Biological processadenosine metabolic process
GO_0006772Biological processthiamine metabolic process
GO_0016311Biological processdephosphorylation
GO_0060168Biological processpositive regulation of adenosine receptor signaling pathway
GO_0006629Biological processlipid metabolic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0031985Cellular componentGolgi cisterna
GO_0012506Cellular componentvesicle membrane
GO_0005764Cellular componentlysosome
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0030175Cellular componentfilopodium
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_0045177Cellular componentapical part of cell
GO_0005765Cellular componentlysosomal membrane
GO_0033265Molecular functioncholine binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0003993Molecular functionacid phosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0042131Molecular functionthiamine phosphate phosphatase activity
GO_0008253Molecular function5'-nucleotidase activity
GO_0052642Molecular functionlysophosphatidic acid phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_0106411Molecular functionXMP 5'-nucleosidase activity
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameACP3
Protein nameProstatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]
acid phosphatase (EC 3.1.3.2)
ACPP (Acid phosphatase (EC 3.1.3.2)) (Prostatic acid phosphotase)
Acid phosphatase 3
SynonymsACPP
DescriptionFUNCTION: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins . Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma . .; FUNCTION: [Isoform 2]: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling . In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity). .; FUNCTION: [PAPf39]: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection . SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea . Target cell attachment and enhancement of HIV infection is inhibited by surfen . Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection . .

AccessionsQ6LBH1
ENST00000475741.5 [P15309-3]
E9PFE6
ENST00000495911.5
ENST00000336375.10 [P15309-1]
ENST00000351273.12 [P15309-2]
A0PJ86
ENST00000507647.1
P15309
H0Y8T3