ACLY report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006633Biological processfatty acid biosynthetic process
GO_0015936Biological processcoenzyme A metabolic process
GO_0006101Biological processcitrate metabolic process
GO_0006085Biological processacetyl-CoA biosynthetic process
GO_0008610Biological processlipid biosynthetic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0006107Biological processoxaloacetate metabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding
GO_0003878Molecular functionATP citrate synthase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACLY
Protein nameATP citrate synthase (EC 2.3.3.8)
ATP citrate lyase
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
Synonymsprotein
variant
DescriptionFUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. .

FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. .

AccessionsENST00000353196.5 [P53396-2]
ENST00000590151.5 [P53396-1]
ENST00000352035.7 [P53396-1]
ENST00000393896.6 [P53396-2]
Q4LE36
ENST00000590770.5
K7ESG8
K7EIE7
ENST00000537919.5 [P53396-3]
ENST00000592970.1
P53396