Name | Number of supported studies | Average coverage | |
---|---|---|---|
adipocyte | 7 studies | 34% ± 18% | |
epithelial cell | 6 studies | 30% ± 13% | |
endothelial cell | 5 studies | 24% ± 7% | |
goblet cell | 5 studies | 30% ± 10% | |
pancreatic A cell | 3 studies | 54% ± 28% | |
type B pancreatic cell | 3 studies | 54% ± 25% | |
classical monocyte | 3 studies | 23% ± 4% | |
retinal ganglion cell | 3 studies | 57% ± 24% | |
endothelial cell of lymphatic vessel | 3 studies | 21% ± 4% | |
ciliated cell | 3 studies | 30% ± 8% | |
abnormal cell | 3 studies | 30% ± 8% | |
astrocyte | 3 studies | 20% ± 3% | |
GABAergic neuron | 3 studies | 25% ± 2% | |
glutamatergic neuron | 3 studies | 24% ± 4% | |
dendritic cell | 3 studies | 26% ± 6% | |
enteroendocrine cell | 3 studies | 26% ± 6% | |
basal cell | 3 studies | 16% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 6409.36 | 578 / 578 | 100% | 118.21 | 1155 / 1155 |
prostate | 100% | 6944.59 | 245 / 245 | 100% | 247.05 | 502 / 502 |
esophagus | 100% | 4868.46 | 1444 / 1445 | 100% | 153.24 | 183 / 183 |
stomach | 100% | 4633.77 | 359 / 359 | 100% | 117.37 | 285 / 286 |
breast | 100% | 9418.16 | 459 / 459 | 100% | 152.99 | 1114 / 1118 |
intestine | 100% | 5297.04 | 966 / 966 | 99% | 119.48 | 524 / 527 |
skin | 100% | 8891.90 | 1809 / 1809 | 99% | 157.16 | 468 / 472 |
pancreas | 100% | 4513.43 | 327 / 328 | 99% | 104.64 | 177 / 178 |
bladder | 100% | 5332.67 | 21 / 21 | 99% | 112.03 | 498 / 504 |
brain | 98% | 4207.75 | 2578 / 2642 | 100% | 128.67 | 705 / 705 |
uterus | 100% | 5879.21 | 170 / 170 | 97% | 90.89 | 445 / 459 |
thymus | 100% | 5825.45 | 653 / 653 | 96% | 63.65 | 582 / 605 |
kidney | 100% | 5369.24 | 89 / 89 | 95% | 205.97 | 860 / 901 |
adrenal gland | 100% | 5706.81 | 258 / 258 | 90% | 93.81 | 207 / 230 |
ovary | 100% | 4062.89 | 180 / 180 | 89% | 50.86 | 384 / 430 |
liver | 92% | 2739.23 | 208 / 226 | 82% | 51.96 | 332 / 406 |
adipose | 100% | 10952.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5949.11 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 102.51 | 29 / 29 |
spleen | 100% | 5921.03 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 47.21 | 1 / 1 |
heart | 94% | 2719.42 | 810 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 63.59 | 75 / 80 |
tonsil | 0% | 0 | 0 / 0 | 93% | 79.53 | 42 / 45 |
peripheral blood | 93% | 5327.65 | 863 / 929 | 0% | 0 | 0 / 0 |
muscle | 85% | 1631.22 | 683 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006633 | Biological process | fatty acid biosynthetic process |
GO_0015936 | Biological process | coenzyme A metabolic process |
GO_0006101 | Biological process | citrate metabolic process |
GO_0006085 | Biological process | acetyl-CoA biosynthetic process |
GO_0008610 | Biological process | lipid biosynthetic process |
GO_0006695 | Biological process | cholesterol biosynthetic process |
GO_0006107 | Biological process | oxaloacetate metabolic process |
GO_0035578 | Cellular component | azurophil granule lumen |
GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005576 | Cellular component | extracellular region |
GO_0016020 | Cellular component | membrane |
GO_0005515 | Molecular function | protein binding |
GO_0003878 | Molecular function | ATP citrate synthase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | ACLY |
Protein name | ATP citrate synthase (EC 2.3.3.8) ATP citrate lyase ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) |
Synonyms | protein variant |
Description | FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. . FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. . |
Accessions | ENST00000353196.5 [P53396-2] ENST00000590151.5 [P53396-1] ENST00000352035.7 [P53396-1] ENST00000393896.6 [P53396-2] Q4LE36 ENST00000590770.5 K7ESG8 K7EIE7 ENST00000537919.5 [P53396-3] ENST00000592970.1 P53396 |