Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 7 studies | 34% ± 18% | |
| epithelial cell | 6 studies | 30% ± 13% | |
| endothelial cell | 5 studies | 24% ± 7% | |
| goblet cell | 5 studies | 30% ± 10% | |
| pancreatic A cell | 3 studies | 54% ± 28% | |
| type B pancreatic cell | 3 studies | 54% ± 25% | |
| classical monocyte | 3 studies | 23% ± 4% | |
| retinal ganglion cell | 3 studies | 57% ± 24% | |
| endothelial cell of lymphatic vessel | 3 studies | 21% ± 4% | |
| ciliated cell | 3 studies | 30% ± 8% | |
| abnormal cell | 3 studies | 30% ± 8% | |
| astrocyte | 3 studies | 20% ± 3% | |
| GABAergic neuron | 3 studies | 25% ± 2% | |
| glutamatergic neuron | 3 studies | 24% ± 4% | |
| dendritic cell | 3 studies | 26% ± 6% | |
| enteroendocrine cell | 3 studies | 26% ± 6% | |
| basal cell | 3 studies | 16% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 6409.36 | 578 / 578 | 100% | 118.21 | 1155 / 1155 |
| prostate | 100% | 6944.59 | 245 / 245 | 100% | 247.05 | 502 / 502 |
| esophagus | 100% | 4868.46 | 1444 / 1445 | 100% | 153.24 | 183 / 183 |
| stomach | 100% | 4633.77 | 359 / 359 | 100% | 117.37 | 285 / 286 |
| breast | 100% | 9418.16 | 459 / 459 | 100% | 152.99 | 1114 / 1118 |
| intestine | 100% | 5297.04 | 966 / 966 | 99% | 119.48 | 524 / 527 |
| skin | 100% | 8891.90 | 1809 / 1809 | 99% | 157.16 | 468 / 472 |
| pancreas | 100% | 4513.43 | 327 / 328 | 99% | 104.64 | 177 / 178 |
| bladder | 100% | 5332.67 | 21 / 21 | 99% | 112.03 | 498 / 504 |
| brain | 98% | 4207.75 | 2578 / 2642 | 100% | 128.67 | 705 / 705 |
| uterus | 100% | 5879.21 | 170 / 170 | 97% | 90.89 | 445 / 459 |
| thymus | 100% | 5825.45 | 653 / 653 | 96% | 63.65 | 582 / 605 |
| kidney | 100% | 5369.24 | 89 / 89 | 95% | 205.97 | 860 / 901 |
| adrenal gland | 100% | 5706.81 | 258 / 258 | 90% | 93.81 | 207 / 230 |
| ovary | 100% | 4062.89 | 180 / 180 | 89% | 50.86 | 384 / 430 |
| liver | 92% | 2739.23 | 208 / 226 | 82% | 51.96 | 332 / 406 |
| adipose | 100% | 10952.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5949.11 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 102.51 | 29 / 29 |
| spleen | 100% | 5921.03 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 47.21 | 1 / 1 |
| heart | 94% | 2719.42 | 810 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 63.59 | 75 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 79.53 | 42 / 45 |
| peripheral blood | 93% | 5327.65 | 863 / 929 | 0% | 0 | 0 / 0 |
| muscle | 85% | 1631.22 | 683 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006633 | Biological process | fatty acid biosynthetic process |
| GO_0015936 | Biological process | coenzyme A metabolic process |
| GO_0006101 | Biological process | citrate metabolic process |
| GO_0006085 | Biological process | acetyl-CoA biosynthetic process |
| GO_0008610 | Biological process | lipid biosynthetic process |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0006107 | Biological process | oxaloacetate metabolic process |
| GO_0035578 | Cellular component | azurophil granule lumen |
| GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0003878 | Molecular function | ATP citrate synthase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ACLY |
| Protein name | ATP citrate synthase (EC 2.3.3.8) ATP citrate lyase ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) |
| Synonyms | protein variant |
| Description | FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. . FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. . |
| Accessions | ENST00000353196.5 [P53396-2] ENST00000590151.5 [P53396-1] ENST00000352035.7 [P53396-1] ENST00000393896.6 [P53396-2] Q4LE36 ENST00000590770.5 K7ESG8 K7EIE7 ENST00000537919.5 [P53396-3] ENST00000592970.1 P53396 |