ACE2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACE2 at tissue level.

III. Associated gene sets

GO_2000272Biological processnegative regulation of signaling receptor activity
GO_0019229Biological processregulation of vasoconstriction
GO_0003081Biological processregulation of systemic arterial blood pressure by renin-angiotensin
GO_0061025Biological processmembrane fusion
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0060452Biological processpositive regulation of cardiac muscle contraction
GO_0098670Biological processentry receptor-mediated virion attachment to host cell
GO_0050727Biological processregulation of inflammatory response
GO_0097746Biological processblood vessel diameter maintenance
GO_0046813Biological processreceptor-mediated virion attachment to host cell
GO_0051957Biological processpositive regulation of amino acid transport
GO_1903598Biological processpositive regulation of gap junction assembly
GO_0046718Biological processsymbiont entry into host cell
GO_0002003Biological processangiotensin maturation
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0019065Biological processreceptor-mediated endocytosis of virus by host cell
GO_0001817Biological processregulation of cytokine production
GO_0019058Biological processviral life cycle
GO_0003051Biological processangiotensin-mediated drinking behavior
GO_1903779Biological processregulation of cardiac conduction
GO_1905737Biological processpositive regulation of L-proline import across plasma membrane
GO_0022898Biological processregulation of transmembrane transporter activity
GO_0015827Biological processtryptophan transport
GO_0042127Biological processregulation of cell population proliferation
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005929Cellular componentcilium
GO_0008241Molecular functionpeptidyl-dipeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0001618Molecular functionvirus receptor activity
GO_0004181Molecular functionmetallocarboxypeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0004180Molecular functioncarboxypeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACE2
Protein nameAngiotensin-converting enzyme (EC 3.4.-.-)
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
Angiotensin converting enzyme 2
SynonymsUNQ868/PRO1885
DescriptionFUNCTION: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis . Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II . Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin . Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency . In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity . .; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. .; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. .; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. .

AccessionsENST00000678046.1
A0A8S0M502
A0A7I2V4H0
ENST00000679278.1
A0A7I2V2E9
ENST00000680121.1 [Q9BYF1-1]
A0A7I2V3N4
ENST00000679212.1
ENST00000427411.2 [Q9BYF1-1]
ENST00000678073.1 [Q9BYF1-1]
Q9BYF1
ENST00000252519.8 [Q9BYF1-1]
A0A7I2V3X6
ENST00000471548.5
ENST00000679162.1
ENST00000677282.1 [Q9BYF1-3]
A0A7I2V5W5