ACADL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACADL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	3296.62	653 / 653	95%	15.09	573 / 605
kidney	100%	1118.26	89 / 89	94%	24.60	851 / 901
prostate	97%	2791.58	238 / 245	96%	21.11	484 / 502
liver	99%	1382.08	224 / 226	61%	5.27	248 / 406
pancreas	100%	2046.20	328 / 328	24%	0.84	42 / 178
lung	88%	1162.45	508 / 578	28%	1.37	319 / 1155
blood vessel	99%	2978.91	1323 / 1335	0%	0	0 / 0
ovary	97%	1548.64	175 / 180	1%	0.04	4 / 430
adipose	95%	804.48	1141 / 1204	0%	0	0 / 0
muscle	88%	498.51	709 / 803	0%	0	0 / 0
breast	80%	1051.17	368 / 459	8%	0.49	86 / 1118
stomach	77%	487.17	275 / 359	0%	0	0 / 286
skin	46%	186.78	838 / 1809	2%	0.07	8 / 472
uterus	24%	116.19	41 / 170	17%	0.89	78 / 459
adrenal gland	12%	44.77	31 / 258	22%	3.75	50 / 230
heart	27%	117.08	235 / 861	0%	0	0 / 0
brain	8%	32.22	214 / 2642	14%	0.68	100 / 705
bladder	5%	18.33	1 / 21	11%	0.60	54 / 504
esophagus	11%	65.58	160 / 1445	3%	0.11	6 / 183
intestine	3%	15.21	27 / 966	2%	0.07	13 / 527
tonsil	0%	0	0 / 0	2%	2.03	1 / 45
spleen	0%	1.57	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0090181	Biological process	regulation of cholesterol metabolic process
GO_0042413	Biological process	carnitine catabolic process
GO_0019254	Biological process	carnitine metabolic process, CoA-linked
GO_0046322	Biological process	negative regulation of fatty acid oxidation
GO_0033539	Biological process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO_0045717	Biological process	negative regulation of fatty acid biosynthetic process
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0001659	Biological process	temperature homeostasis
GO_0042758	Biological process	long-chain fatty acid catabolic process
GO_0044242	Biological process	cellular lipid catabolic process
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0042802	Molecular function	identical protein binding
GO_0016401	Molecular function	palmitoyl-CoA oxidase activity
GO_0004466	Molecular function	long-chain fatty acyl-CoA dehydrogenase activity
GO_0000062	Molecular function	fatty-acyl-CoA binding
GO_0005515	Molecular function	protein binding

Gene name	ACADL
Protein name	Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)
Synonyms
Description	FUNCTION: Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains . .
Accessions	P28330 ENST00000233710.4

ACADL report