ABCG8 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCG8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	4373.60	226 / 226	88%	23.81	358 / 406
brain	83%	26.12	2181 / 2642	0%	0	0 / 705
adrenal gland	56%	6.90	145 / 258	10%	0.30	23 / 230
intestine	50%	97.16	482 / 966	11%	0.31	56 / 527
spleen	53%	15.83	127 / 241	0%	0	0 / 0
stomach	21%	2.17	75 / 359	14%	0.37	39 / 286
kidney	28%	10.28	25 / 89	6%	0.17	55 / 901
adipose	31%	4.90	374 / 1204	0%	0	0 / 0
ovary	24%	2.38	43 / 180	6%	0.15	27 / 430
uterus	28%	11.21	47 / 170	0%	0.01	2 / 459
breast	22%	2.85	99 / 459	0%	0.01	3 / 1118
esophagus	7%	0.76	104 / 1445	14%	0.59	25 / 183
lung	8%	0.55	46 / 578	4%	0.09	41 / 1155
pancreas	5%	0.36	15 / 328	6%	0.15	11 / 178
heart	10%	0.99	88 / 861	0%	0	0 / 0
thymus	9%	0.66	59 / 653	0%	0	0 / 605
skin	8%	0.68	148 / 1809	0%	0	0 / 472
peripheral blood	7%	1.15	63 / 929	0%	0	0 / 0
prostate	7%	0.42	16 / 245	0%	0	0 / 502
blood vessel	4%	0.38	48 / 1335	0%	0	0 / 0
bladder	0%	0	0 / 21	3%	0.04	13 / 504
muscle	2%	0.12	14 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007584	Biological process	response to nutrient
GO_0070328	Biological process	triglyceride homeostasis
GO_0015914	Biological process	phospholipid transport
GO_0030299	Biological process	intestinal cholesterol absorption
GO_0015918	Biological process	sterol transport
GO_0055085	Biological process	transmembrane transport
GO_0045796	Biological process	negative regulation of intestinal cholesterol absorption
GO_0014850	Biological process	response to muscle activity
GO_0038183	Biological process	bile acid signaling pathway
GO_0033344	Biological process	cholesterol efflux
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010949	Biological process	negative regulation of intestinal phytosterol absorption
GO_0042632	Biological process	cholesterol homeostasis
GO_0016324	Cellular component	apical plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0043190	Cellular component	ATP-binding cassette (ABC) transporter complex
GO_0140359	Molecular function	ABC-type transporter activity
GO_0120020	Molecular function	cholesterol transfer activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0042626	Molecular function	ATPase-coupled transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

Gene name	ABCG8
Protein name	ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) ATP binding cassette subfamily G member 8 ATP-binding cassette, sub-family G (WHITE), member 8 ABCG8 protein Sterolin 2
Synonyms
Description	FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile . Required for normal sterol homeostasis . The heterodimer with ABCG5 has ATPase activity . .
Accessions	B7ZL41 A0A2R8Y6M1 Q9H221 ENST00000272286.4 [Q9H221-1] Q14CR0 Q96A01 ENST00000644611.1

ABCG8 report