ABCG5 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	3 studies	42% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCG5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	7517.35	226 / 226	91%	29.49	371 / 406
adrenal gland	97%	20.22	250 / 258	14%	0.45	32 / 230
intestine	84%	52.36	814 / 966	23%	0.64	120 / 527
kidney	91%	19.44	81 / 89	14%	0.36	128 / 901
ovary	95%	13.08	171 / 180	8%	0.13	33 / 430
uterus	95%	24.52	162 / 170	2%	0.02	7 / 459
brain	97%	22.72	2554 / 2642	0%	0.00	1 / 705
spleen	94%	34.61	227 / 241	0%	0	0 / 0
esophagus	70%	5.82	1016 / 1445	21%	0.98	39 / 183
thymus	91%	10.42	596 / 653	0%	0	0 / 605
prostate	89%	8.84	219 / 245	0%	0.00	2 / 502
stomach	64%	4.46	228 / 359	26%	0.78	74 / 286
lung	82%	8.28	474 / 578	6%	0.19	72 / 1155
breast	87%	10.45	400 / 459	1%	0.02	11 / 1118
adipose	86%	10.80	1033 / 1204	0%	0	0 / 0
skin	65%	6.15	1170 / 1809	19%	0.44	89 / 472
bladder	67%	4.33	14 / 21	6%	0.13	31 / 504
blood vessel	70%	5.19	932 / 1335	0%	0	0 / 0
pancreas	59%	3.77	193 / 328	10%	0.37	18 / 178
heart	62%	4.12	538 / 861	0%	0	0 / 0
muscle	33%	1.68	266 / 803	0%	0	0 / 0
peripheral blood	28%	3.11	258 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	14%	0.76	4 / 29
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007584	Biological process	response to nutrient
GO_0070328	Biological process	triglyceride homeostasis
GO_0030299	Biological process	intestinal cholesterol absorption
GO_0015918	Biological process	sterol transport
GO_0010212	Biological process	response to ionizing radiation
GO_0055085	Biological process	transmembrane transport
GO_0045796	Biological process	negative regulation of intestinal cholesterol absorption
GO_0014850	Biological process	response to muscle activity
GO_0038183	Biological process	bile acid signaling pathway
GO_0033344	Biological process	cholesterol efflux
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010949	Biological process	negative regulation of intestinal phytosterol absorption
GO_0042632	Biological process	cholesterol homeostasis
GO_0016324	Cellular component	apical plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0043190	Cellular component	ATP-binding cassette (ABC) transporter complex
GO_0140359	Molecular function	ABC-type transporter activity
GO_0120020	Molecular function	cholesterol transfer activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0042626	Molecular function	ATPase-coupled transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

Gene name	ABCG5
Protein name	ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1) Uncharacterized protein ABCG5
Synonyms
Description	FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane . Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile . Required for normal sterol homeostasis . The heterodimer with ABCG8 has ATPase activity . .
Accessions	Q9H222 ENST00000405322.8 [Q9H222-1] Q53T83 Q53QN9

ABCG5 report