ABCD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015910Biological processlong-chain fatty acid import into peroxisome
GO_0055085Biological processtransmembrane transport
GO_0015889Biological processcobalamin transport
GO_0042760Biological processvery long-chain fatty acid catabolic process
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0009235Biological processcobalamin metabolic process
GO_0007031Biological processperoxisome organization
GO_0006635Biological processfatty acid beta-oxidation
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043190Cellular componentATP-binding cassette (ABC) transporter complex
GO_0005777Cellular componentperoxisome
GO_0005765Cellular componentlysosomal membrane
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0015420Molecular functionABC-type vitamin B12 transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCD4
Protein nameATP binding cassette subfamily D member 4
Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69)
SynonymsPXMP1L
DescriptionFUNCTION: Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner . Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane . Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane . .

AccessionsENST00000555617.5
O14678
ENST00000460308.6
H0YJ78
H0YJX8
ENST00000474270.1
ENST00000556971.1
E9PPB6
ENST00000553998.5
ENST00000481348.5
H0YCY9
ENST00000469672.5
ENST00000553745.5
G3V3W1
ENST00000356924.9
ENST00000481935.5
ENST00000556517.1
ENST00000556119.5
H0YJL8
ENST00000554453.5
ENST00000555904.1
ENST00000553486.5
G3V4U7
ENST00000557588.5
ENST00000470637.1
H0YJ82
E9PI46