Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 23% ± 8% | |
vein endothelial cell | 6 studies | 21% ± 10% | |
glutamatergic neuron | 5 studies | 32% ± 19% | |
epithelial cell | 4 studies | 33% ± 13% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 5% | |
endothelial cell of vascular tree | 4 studies | 21% ± 4% | |
GABAergic neuron | 4 studies | 36% ± 15% | |
oligodendrocyte | 4 studies | 21% ± 3% | |
macrophage | 4 studies | 18% ± 2% | |
fibroblast | 3 studies | 18% ± 2% | |
astrocyte | 3 studies | 29% ± 3% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 2% | |
neuron | 3 studies | 28% ± 10% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 32% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
uterus | 100% | 3578.69 | 170 / 170 | 100% | 14.57 | 459 / 459 |
kidney | 100% | 3215.28 | 89 / 89 | 100% | 17.84 | 900 / 901 |
brain | 100% | 2214.89 | 2637 / 2642 | 100% | 21.70 | 705 / 705 |
intestine | 100% | 2705.03 | 966 / 966 | 100% | 11.91 | 526 / 527 |
bladder | 100% | 2699.10 | 21 / 21 | 100% | 13.12 | 503 / 504 |
lung | 100% | 2603.84 | 578 / 578 | 100% | 11.89 | 1152 / 1155 |
thymus | 100% | 3625.91 | 653 / 653 | 100% | 20.05 | 603 / 605 |
stomach | 100% | 1741.28 | 359 / 359 | 100% | 9.80 | 285 / 286 |
prostate | 100% | 2824.05 | 245 / 245 | 100% | 12.19 | 500 / 502 |
esophagus | 100% | 2243.87 | 1445 / 1445 | 99% | 10.25 | 182 / 183 |
skin | 100% | 1910.87 | 1808 / 1809 | 99% | 13.00 | 469 / 472 |
ovary | 100% | 3679.91 | 180 / 180 | 99% | 11.44 | 427 / 430 |
liver | 100% | 1969.65 | 226 / 226 | 99% | 10.78 | 403 / 406 |
pancreas | 100% | 1332.60 | 328 / 328 | 99% | 15.99 | 176 / 178 |
breast | 100% | 3424.07 | 459 / 459 | 99% | 10.94 | 1104 / 1118 |
adrenal gland | 100% | 2479.41 | 258 / 258 | 94% | 8.34 | 217 / 230 |
adipose | 100% | 3330.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 14.40 | 29 / 29 |
spleen | 100% | 3699.33 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 10.49 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.39 | 1 / 1 |
blood vessel | 100% | 1858.94 | 1332 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 1423.30 | 857 / 861 | 0% | 0 | 0 / 0 |
muscle | 98% | 939.41 | 786 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 11.44 | 77 / 80 |
peripheral blood | 83% | 899.66 | 773 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015910 | Biological process | long-chain fatty acid import into peroxisome |
GO_0055085 | Biological process | transmembrane transport |
GO_0015889 | Biological process | cobalamin transport |
GO_0042760 | Biological process | very long-chain fatty acid catabolic process |
GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
GO_0009235 | Biological process | cobalamin metabolic process |
GO_0007031 | Biological process | peroxisome organization |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0043190 | Cellular component | ATP-binding cassette (ABC) transporter complex |
GO_0005777 | Cellular component | peroxisome |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005324 | Molecular function | long-chain fatty acid transmembrane transporter activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0015420 | Molecular function | ABC-type vitamin B12 transporter activity |
GO_0005524 | Molecular function | ATP binding |
GO_0042626 | Molecular function | ATPase-coupled transmembrane transporter activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ABCD4 |
Protein name | ATP binding cassette subfamily D member 4 Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) |
Synonyms | PXMP1L |
Description | FUNCTION: Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner . Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane . Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane . . |
Accessions | ENST00000555617.5 O14678 ENST00000460308.6 H0YJ78 H0YJX8 ENST00000474270.1 ENST00000556971.1 E9PPB6 ENST00000553998.5 ENST00000481348.5 H0YCY9 ENST00000469672.5 ENST00000553745.5 G3V3W1 ENST00000356924.9 ENST00000481935.5 ENST00000556517.1 ENST00000556119.5 H0YJL8 ENST00000554453.5 ENST00000555904.1 ENST00000553486.5 G3V4U7 ENST00000557588.5 ENST00000470637.1 H0YJ82 E9PI46 |