ABCC6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCC6 at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0055062Biological processphosphate ion homeostasis
GO_0007601Biological processvisual perception
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0030643Biological processintracellular phosphate ion homeostasis
GO_0032026Biological processresponse to magnesium ion
GO_0015867Biological processATP transport
GO_0055085Biological processtransmembrane transport
GO_0046034Biological processATP metabolic process
GO_1904383Biological processresponse to sodium phosphate
GO_0030505Biological processinorganic diphosphate transport
GO_0140928Biological processinhibition of non-skeletal tissue mineralization
GO_0010467Biological processgene expression
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0071716Biological processleukotriene transport
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0009925Cellular componentbasal plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0043225Molecular functionATPase-coupled inorganic anion transmembrane transporter activity
GO_0015431Molecular functionABC-type glutathione S-conjugate transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCC6
Protein nameATP-binding cassette sub-family C member 6
ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3)
ATP binding cassette subfamily C member 6 (ATP-binding cassette sub-family C member 6)
ATP binding cassette subfamily C member 6
SynonymsMRP6
ARA
DescriptionFUNCTION: [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 . May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin . .; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. .; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. .

AccessionsA0A0G2JMG3
ENST00000620078.4
A0A1W2PPQ8
ENST00000638420.1
ENST00000574094.6
ENST00000632157.1
ENST00000205557.12 [O95255-1]
A0A8C8Q0G8
ENST00000622290.5
ENST00000575728.1 [O95255-2]
I3L1Z6
ENST00000633611.1
ENST00000456970.6 [O95255-3]
A0A804HJ04
ENST00000600761.3 [O95255-2]
O95255
A0A0J9YVW5
ENST00000577103.1